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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vgp AD6 Aurora kinase B-A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vgp AD6Aurora kinase B-A 2.7.11.1 0.875
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.703
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.702
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.700
4b0g VEKAurora kinase A 2.7.11.1 0.687
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.683
2xng A0HAurora kinase A 2.7.11.1 0.682
2xne ASHAurora kinase A 2.7.11.1 0.681
4jaj XU1Aurora kinase A 2.7.11.1 0.681
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.675
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.675
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.674
2vrx 447Aurora kinase B-A 2.7.11.1 0.671
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.670
2x6d X6DAurora kinase A 2.7.11.1 0.665
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.664
2btr U73Cyclin-dependent kinase 2 2.7.11.22 0.663
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.662
4jbq VX6Aurora kinase A 2.7.11.1 0.657
4gmy 0X5Tyrosine-protein kinase JAK2 / 0.656
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.651
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.650