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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pg0 FAD Acyl-CoA dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pg0 FADAcyl-CoA dehydrogenase / 1.396
4p13 FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 1.121
2vig FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.1 1.077
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 1.069
3oib FDAPutative acyl-CoA dehydrogenase / 1.063
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 1.049
3p4t FAOPutative acyl-CoA dehydrogenase / 1.045
5jsc FADPutative acyl-CoA dehydrogenase / 1.015
3pfd FDAAcyl-CoA dehydrogenase FadE25 / 0.995
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.984
4iv6 FDAIsovaleryl-CoA dehydrogenase / 0.974
1rx0 FADIsobutyryl-CoA dehydrogenase, mitochondrial 1.3.99 0.967
4m9a FDAAcyl-CoA dehydrogenase / 0.930
3sf6 FDAGlutaryl-CoA dehydrogenase / 0.916
5af7 FADAcyl-CoA dehydrogenase / 0.907
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.903
1udy FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.903
2eba FADPutative glutaryl-CoA dehydrogenase / 0.901
1egd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.898
3u33 FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.898
5ahs FADAcyl-CoA dehydrogenase / 0.877
2z1q FADAcyl-CoA dehydrogenase / 0.869
4y9l FADAcyl-CoA dehydrogenase family member 11 / 0.869
2ix5 FADAcyl-coenzyme A oxidase 4, peroxisomal 1.3.3.6 0.864
3r7k FDAProbable acyl CoA dehydrogenase / 0.861
1ege FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.860
4x28 FDAAcyl-CoA dehydrogenase FadE26 / 0.842
4x28 FDAAcyl-CoA dehydrogenase FadE27 / 0.842
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.839
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.837
3owa FADAcyl-CoA dehydrogenase / 0.837
2dvl FADAcyl-CoA dehydrogenase / 0.830
3mpj FADGlutaryl-CoA dehydrogenase 1.3.99.32 0.819
1u8v FAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase / 0.812
4kto FADPutative isovaleryl-CoA dehydrogenase protein / 0.801
1t9g FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.795
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.793
4irn FADAnaB / 0.784
2c12 FADNitroalkane oxidase 1.7.3.1 0.762
2fon FADAcyl-coenzyme A oxidase / 0.742
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.738
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.729
2yyl FAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component 1.14.14.9 0.724
1r2j FADFkbI / 0.714
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.714
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.711
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.708
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.703
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.697
2h8x FMNXenA / 0.693
1a8p FADFerredoxin--NADP reductase / 0.691
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.689
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.687
3klb FMNUncharacterized protein / 0.683
2d29 FADAcyl-CoA dehydrogenase / 0.682
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.682
1yki FMNOxygen-insensitive NAD(P)H nitroreductase / 0.680
3n19 FNRXenobiotic reductase / 0.679
3n39 FMNProtein NrdI / 0.679
1vhn FMNtRNA-dihydrouridine synthase / 0.678
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.678
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.676
2yyi FAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component 1.14.14.9 0.675
3fcj FADNitroalkane oxidase 1.7.3.1 0.674
3mkh FADNitroalkane oxidase / 0.674
4hh0 FMNAppA protein / 0.674
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.673
4cw5 FMNDfnA / 0.669
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.669
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.668
4hnb FMNLOV protein / 0.668
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.667
5a89 FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.667
3pxv FMNNitroreductase / 0.666
4h6r FDAProline dehydrogenase / 0.666
2zaf FADNitroalkane oxidase 1.7.3.1 0.665
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.665
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.664
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.664
3lsh FADPyranose 2-oxidase / 0.664
5i39 FADL-amino acid deaminase / 0.664
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.663
1oo5 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.662
1p0n FMNIsopentenyl-diphosphate delta-isomerase / 0.662
3l67 FMNXenobiotic reductase / 0.662
1t6z RBFRiboflavin biosynthesis protein / 0.661
1ylu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.660
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.660
4opl FDAConserved Archaeal protein / 0.660
4zoh FADPutative oxidoreductase FAD-binding subunit / 0.660
5kbw RBFRiboflavin transporter RibU / 0.660
4h6p FMNChromate reductase / 0.659
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.658
4ttc FMNIodotyrosine deiodinase 1 / 0.658
1n4v FADCholesterol oxidase 1.1.3.6 0.657
2nli FMNLactate oxidase / 0.657
3gyi FADCholesterol oxidase 1.1.3.6 0.656
2zfa FMNLactate oxidase / 0.655
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.654
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.652
3b6d FAECholesterol oxidase 1.1.3.6 0.652
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.652
2vxa RBFDodecin / 0.651
3rha FDAPutrescine oxidase / 0.651
1yob FMNFlavodoxin 2 / 0.650