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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2p9c NAI D-3-phosphoglycerate dehydrogenase 1.1.1.95

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 1.000
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.883
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.861
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.847
3oet NADErythronate-4-phosphate dehydrogenase / 0.776
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.754
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.746
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.744
2o4c NADErythronate-4-phosphate dehydrogenase / 0.729
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.712
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.711
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.708
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.705
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.699
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.696
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.694
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.691
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.687
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.686
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.684
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.680
1hku NADC-terminal-binding protein 1 1.1.1 0.679
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.678
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.677
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.675
2ome NADC-terminal-binding protein 2 / 0.673
2a92 NAIL-lactate dehydrogenase / 0.672
4ros APRMalate dehydrogenase / 0.672
1sow NADL-lactate dehydrogenase 1.1.1.27 0.671
2x0i NAIMalate dehydrogenase / 0.671
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.670
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.670
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
5a1t NAIL-lactate dehydrogenase / 0.669
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.667
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.664
1pzh NADLactate dehydrogenase / 0.663
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.661
3kb6 NADD-lactate dehydrogenase / 0.661
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.660
2dph NADFormaldehyde dismutase / 0.659
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.659
1x7d NADPutative ornithine cyclodeaminase / 0.658
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.657
1f8f NADBenzyl alcohol dehydrogenase / 0.656
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.656
4xyb NDPFormate dehydrogenase / 0.656
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.655
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.655
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.653
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.652
2aa3 AP0L-lactate dehydrogenase / 0.652
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.651
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.651
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.651
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.651
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.651
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.650
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.650