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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j7x EST Estrogen receptor beta

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j7x ESTEstrogen receptor beta / 1.191
4j24 ESTEstrogen receptor beta / 1.069
3oll ESTEstrogen receptor beta / 1.051
5dxg ESTEstrogen receptor / 1.047
3uud ESTEstrogen receptor / 1.013
4pxm ESTEstrogen receptor / 0.998
2qgt EEDEstrogen receptor / 0.973
1gwr ESTEstrogen receptor / 0.964
5hyr ESTEstrogen receptor / 0.961
2g5o DRQEstrogen receptor / 0.957
5dx3 ESTEstrogen receptor / 0.941
3q95 ESLEstrogen receptor / 0.934
3l03 4OHEstrogen receptor / 0.921
2yja ESTEstrogen receptor / 0.919
2ocf ESTEstrogen receptor / 0.891
2yat EEUEstrogen receptor / 0.875
2b1z 17MEstrogen receptor / 0.870
1g50 ESTEstrogen receptor / 0.864
2p15 EZTEstrogen receptor / 0.843
4j26 ESTEstrogen receptor beta / 0.784
3ols ESTEstrogen receptor beta / 0.772
1x7e 244Estrogen receptor / 0.761
2pog WSTEstrogen receptor / 0.746
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.739
1l2i ETCEstrogen receptor / 0.734
2fai 459Estrogen receptor / 0.725
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.724
2piu DHTAndrogen receptor / 0.714
2pio DHTAndrogen receptor / 0.711
1gwq ZTWEstrogen receptor / 0.709
2pip DHTAndrogen receptor / 0.709
1xq3 R18Androgen receptor / 0.701
1ya3 STRMineralocorticoid receptor / 0.701
2aa7 1CAMineralocorticoid receptor / 0.700
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.698
1kdm DHTSex hormone-binding globulin / 0.696
4hlw TESAndrogen receptor / 0.692
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.691
4oed DHTAndrogen receptor / 0.691
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.683
1lhu ESTSex hormone-binding globulin / 0.682
2pix DHTAndrogen receptor / 0.681
2aa5 STRMineralocorticoid receptor / 0.680
1sqn NDRProgesterone receptor / 0.679
2qe4 JJ3Estrogen receptor / 0.678
1t63 DHTAndrogen receptor / 0.677
2abi 1CAMineralocorticoid receptor / 0.677
3gki CLRNiemann-Pick C1 protein / 0.676
4bb2 STRCorticosteroid-binding globulin / 0.676
1t74 DHTAndrogen receptor / 0.674
4oey DHTAndrogen receptor / 0.674
4pp6 STLEstrogen receptor / 0.674
1t7r DHTAndrogen receptor / 0.673
1xj7 DHTAndrogen receptor / 0.673
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.673
2jn3 JN3Fatty acid-binding protein, liver / 0.672
4lxj LANLanosterol 14-alpha demethylase 1.14.13.70 0.672
3up0 D7SaceDAF-12 / 0.671
2q7i TESAndrogen receptor / 0.669
1xow R18Androgen receptor / 0.668
1yy4 4NAEstrogen receptor beta / 0.668
3w5p 4OAVitamin D3 receptor / 0.668
4e5f 0N7Polymerase acidic protein / 0.665
2piv DHTAndrogen receptor / 0.664
4y8w STRSteroid 21-hydroxylase / 0.664
1x7b 041Estrogen receptor beta / 0.663
2d06 ESTSulfotransferase 1A1 2.8.2.1 0.663
2pir DHTAndrogen receptor / 0.663
3bej MUFBile acid receptor / 0.663
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.663
2pit DHTAndrogen receptor / 0.662
2pnu ENMAndrogen receptor / 0.662
4oez DHTAndrogen receptor / 0.662
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
1s9q OHTEstrogen-related receptor gamma / 0.659
3w5r LOAVitamin D3 receptor / 0.659
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.659
1lho AOMSex hormone-binding globulin / 0.658
1t79 DHTAndrogen receptor / 0.658
4m8e 29VRetinoic acid receptor RXR-alpha / 0.658
4oea DHTAndrogen receptor / 0.658
2aa6 STRMineralocorticoid receptor / 0.655
2q7k TESAndrogen receptor / 0.654
1lhn AONSex hormone-binding globulin / 0.653
2jfa RALEstrogen receptor / 0.653
3zqt TESAndrogen receptor / 0.653
1lri CLRBeta-elicitin cryptogein / 0.652
1aqu ESTEstrogen sulfotransferase, testis isoform 2.8.2.4 0.651
3mb7 14ICasein kinase II subunit alpha 2.7.11.1 0.651
5epo TUD7-alpha-hydroxysteroid deydrogenase / 0.651
3w5q 3KLVitamin D3 receptor / 0.650
4e5l DBHPolymerase acidic protein / 0.650