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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hzi JIN Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 1.178
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.975
2g2h P16Tyrosine-protein kinase ABL1 2.7.10.2 0.863
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.779
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.762
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.754
3fkl FKLMitogen-activated protein kinase 14 / 0.714
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.700
3fsf FSSMitogen-activated protein kinase 14 / 0.700
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.699
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.697
3lfa 1N1Mitogen-activated protein kinase 14 / 0.696
2p2h 994Vascular endothelial growth factor receptor 2 2.7.10.1 0.695
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.693
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.693
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.693
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.685
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.685
4eqc XR1Serine/threonine-protein kinase PAK 1 2.7.11.1 0.682
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.681
2zm1 KSFTyrosine-protein kinase Lck 2.7.10.2 0.681
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.677
4fv9 E71Mitogen-activated protein kinase 1 2.7.11.24 0.676
3fln 3FNMitogen-activated protein kinase 14 / 0.669
3flq 891Mitogen-activated protein kinase 14 / 0.669
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.667
2rg6 287Mitogen-activated protein kinase 14 / 0.665
3ttj JBIMitogen-activated protein kinase 10 2.7.11.24 0.665
3bx5 304Mitogen-activated protein kinase 14 / 0.664
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.663
4grb 0XGCasein kinase II subunit alpha 2.7.11.1 0.663
3uo5 0BXAurora kinase A 2.7.11.1 0.662
2gtm LIDMitogen-activated protein kinase 14 / 0.660
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.660
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.659
2in6 839Wee1-like protein kinase 2.7.10.2 0.653
2obj VRVSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.652
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.651
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.651
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.651
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.650