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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hkj RDC Type 2 DNA topoisomerase 6 subunit B

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.980
4egk RDCHeat shock protein HSP 90-alpha / 0.834
1qy8 RDIEndoplasmin / 0.793
1u0z RDCEndoplasmin / 0.789
2q8i RDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.7.11.2 0.788
3eko PYUHeat shock protein HSP 90-alpha / 0.772
4ce1 7FKATP-dependent molecular chaperone HSP82 / 0.770
4bqj XKLHeat shock protein HSP 90-alpha / 0.754
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.751
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.744
3inw JZBHeat shock protein HSP 90-alpha / 0.743
2wer RDCATP-dependent molecular chaperone HSP82 / 0.741
2yk2 YJWHeat shock protein HSP 90-alpha / 0.736
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.733
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.730
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.729
2ye4 2FYHeat shock protein HSP 90-alpha / 0.725
2xjj L81Heat shock protein HSP 90-alpha / 0.722
2yjw YJWHeat shock protein HSP 90-alpha / 0.719
1bgq RDCATP-dependent molecular chaperone HSP82 / 0.716
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.691
3k99 PFTHeat shock protein HSP 90-alpha / 0.683
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.670
2gfd RDAEndoplasmin / 0.666
4egh 0OYHeat shock protein HSP 90-alpha / 0.666
4e5f 0N7Polymerase acidic protein / 0.660
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.657
4ce3 L4VATP-dependent molecular chaperone HSP82 / 0.656