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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2h8h H8H Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.088
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.808
2itz IREEpidermal growth factor receptor 2.7.10.1 0.764
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.761
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.760
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 0.759
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.721
1m17 AQ4Epidermal growth factor receptor 2.7.10.1 0.710
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.709
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.693
5ajq DB8Serine/threonine-protein kinase 10 2.7.11.1 0.671
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.667
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.666
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.665
2gtm LIDMitogen-activated protein kinase 14 / 0.664
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.656
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.653
2vx1 7X8Ephrin type-B receptor 4 2.7.10.1 0.653