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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g2h P16 Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g2h P16Tyrosine-protein kinase ABL1 2.7.10.2 1.028
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.867
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.863
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.750
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.717
2p2h 994Vascular endothelial growth factor receptor 2 2.7.10.1 0.691
4eqc XR1Serine/threonine-protein kinase PAK 1 2.7.11.1 0.688
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.680
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.680
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.677
3fsk RO6Mitogen-activated protein kinase 14 / 0.674
3fsf FSSMitogen-activated protein kinase 14 / 0.671
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.655
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.650