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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fdd 385 Pol protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2fdd 385Pol protein / 1.407
2qci 065Gag-Pol polyprotein 3.4.23.16 1.076
4hdp G52Gag-Pol polyprotein 3.4.23.16 1.074
4heg G52Gag-Pol polyprotein 3.4.23.16 1.073
3o9a K14Pol polyprotein / 1.069
4kb9 G79Protease / 1.065
3st5 G89Gag-Pol polyprotein 3.4.23.16 1.056
2qd6 065Gag-Pol polyprotein 3.4.23.16 1.051
3pwm 017Gag-Pol polyprotein 3.4.23.16 1.040
4hdf G52Gag-Pol polyprotein 3.4.23.16 1.038
3d20 017Gag-Pol polyprotein 3.4.23.16 1.032
3lzu 017Gag-Pol polyprotein 3.4.23.16 1.028
3o9h K2EGag-Pol polyprotein / 1.028
3ok9 G52Gag-Pol polyprotein 3.4.23.16 1.023
3mws 017Pol protein / 1.021
1t7i 017Gag-Pol polyprotein 3.4.23.16 1.017
3jvy 017Gag-Pol polyprotein 3.4.23.16 1.009
3o9b K2APol polyprotein / 1.006
3lzs 017Gag-Pol polyprotein 3.4.23.16 1.005
4q1w 017Gag-Pol polyprotein 3.4.23.16 1.001
3oy4 017Gag-Pol polyprotein 3.4.23.16 0.999
2qd8 065Gag-Pol polyprotein 3.4.23.16 0.990
1t3r 017Gag-Pol polyprotein 3.4.23.16 0.989
3o9e A60Pol polyprotein / 0.989
4njs G08Protease / 0.989
2f81 017Gag-Pol polyprotein 3.4.23.16 0.985
3lzv 017Gag-Pol polyprotein 3.4.23.16 0.984
3oxw 017Gag-Pol polyprotein 3.4.23.16 0.984
3vfa 031Gag-Pol polyprotein 3.4.23.16 0.979
2ien 017Gag-Pol polyprotein 3.4.23.16 0.978
3o9f K2DGag-Pol polyprotein / 0.978
3o9d K19Pol polyprotein / 0.974
4dqh 017Gag-Pol polyprotein / 0.974
4hdb G52Gag-Pol polyprotein 3.4.23.16 0.974
2qd7 065Gag-Pol polyprotein 3.4.23.16 0.971
3ecg 065Gag-Pol polyprotein 3.4.23.47 0.971
4dfg 0JVGag-Pol polyprotein 3.4.23.16 0.971
2f80 017Gag-Pol polyprotein 3.4.23.16 0.966
3jw2 017Gag-Pol polyprotein 3.4.23.16 0.964
3o9i A61Gag-Pol polyprotein / 0.963
3d1z 017Gag-Pol polyprotein 3.4.23.16 0.962
3i6o GR6Gag-Pol polyprotein 3.4.23.16 0.962
2z4o 065Gag-Pol polyprotein 3.4.23.16 0.957
4j54 G52Gag-Pol polyprotein 3.4.23.16 0.956
3o9c K20Pol polyprotein / 0.955
3ggu 017Gag-Pol polyprotein 3.4.23.16 0.953
3s54 017Protease / 0.952
4djp M73Pol polyprotein / 0.947
3t3c 017Gag-Pol polyprotein 3.4.23.16 0.946
4ye3 G04Gag-Pol polyprotein 3.4.23.16 0.944
2idw 017Protease / 0.942
3sa8 K83Protease / 0.940
3bvb 017Gag-Pol polyprotein 3.4.23.16 0.934
3mxd K53Gag-Pol polyprotein 3.4.23.16 0.934
3sa9 A68Protease / 0.933
2i4u DJRProtease / 0.930
3gi5 K62Gag-Pol polyprotein / 0.929
4dqf 017Gag-Pol polyprotein / 0.929
2fde 385Gag-Pol polyprotein 3.4.23.16 0.928
3o99 K13Pol polyprotein / 0.928
3qaa G04Gag-Pol polyprotein 3.4.23.16 0.926
3em6 017Gag-Pol polyprotein 3.4.23.16 0.924
2f8g 017Gag-Pol polyprotein 3.4.23.16 0.922
3vfb 031Gag-Pol polyprotein 3.4.23.16 0.922
1d4l PI9Gag-Pol polyprotein 3.4.23.16 0.916
2ieo 017Protease / 0.913
3i7e DJRGag-Pol polyprotein / 0.912
4q1y 017Gag-Pol polyprotein 3.4.23.16 0.912
2hs1 017Protease / 0.911
1z1r HBHGag-Pol polyprotein 3.4.23.16 0.909
2hb3 GRLProtease / 0.903
2i0a MUIProtease / 0.903
3sab F78Protease / 0.902
4njt 017Protease / 0.901
3gi4 K60Gag-Pol polyprotein / 0.900
3o9g F53Gag-Pol polyprotein / 0.895
2hs2 017Protease / 0.891
4djo MK5Pol polyprotein / 0.887
3ec0 GRLGag-Pol polyprotein 3.4.23.47 0.886
4dqe 017Gag-Pol polyprotein / 0.885
4q1x 017Gag-Pol polyprotein 3.4.23.16 0.879
3vf7 031Gag-Pol polyprotein 3.4.23.16 0.877
3cyw 017Gag-Pol polyprotein 3.4.23.16 0.876
4dqb 017Gag-Pol polyprotein / 0.875
3gi6 D78Gag-Pol polyprotein / 0.873
2qhy MZ1Gag-Pol polyprotein / 0.871
3ekt 017Gag-Pol polyprotein 3.4.23.16 0.871
2psu MUUProtease / 0.869
3mxe K54Gag-Pol polyprotein 3.4.23.16 0.865
3ekv 478Gag-Pol polyprotein 3.4.23.16 0.860
3ucb 017Gag-Pol polyprotein / 0.857
3vf5 031Gag-Pol polyprotein 3.4.23.16 0.857
4dqc 017Gag-Pol polyprotein / 0.857
3nu5 478Gag-Pol polyprotein 3.4.23.16 0.853
3nu4 478Gag-Pol polyprotein 3.4.23.16 0.851
1yt9 OISGag-Pol polyprotein / 0.842
1z1h HBBGag-Pol polyprotein 3.4.23.16 0.841
2qi0 MZ3Gag-Pol polyprotein / 0.838
3nuo 478Gag-Pol polyprotein 3.4.23.16 0.838
3dk1 G05Gag-Pol polyprotein 3.4.23.16 0.835
2qi6 MZ8Gag-Pol polyprotein / 0.832
3oxv 478Gag-Pol polyprotein 3.4.23.16 0.830
3nu6 478Gag-Pol polyprotein 3.4.23.16 0.829
3em3 478Gag-Pol polyprotein 3.4.23.16 0.826
3sa7 55AProtease / 0.825
3nu3 478Gag-Pol polyprotein 3.4.23.16 0.824
2qi4 MZ6Gag-Pol polyprotein / 0.822
3sa3 23XProtease / 0.822
3sa4 F72Protease / 0.821
2i4d QFIProtease / 0.818
4djr 0KJPol polyprotein / 0.818
4hla 017Gag-Pol polyprotein 3.4.23.16 0.818
2qi3 MZ5Gag-Pol polyprotein / 0.816
3s43 478Protease / 0.816
2i4v DJRV-1 protease / 0.812
2cem 2AHPol protein / 0.811
2i4x KGQProtease / 0.808
1xl5 190Gag-Pol polyprotein 3.4.23.16 0.807
1npv L27Gag-Pol polyprotein 3.4.23.16 0.802
1hpv 478Gag-Pol polyprotein / 0.800
3djk G55Gag-Pol polyprotein 3.4.23.16 0.797
4i8z G08Gag-Pol polyprotein 3.4.23.16 0.794
3sm2 478Putative gag-pro-pol polyprotein / 0.793
2cen 4AHProtease / 0.791
3eky DR7Gag-Pol polyprotein 3.4.23.16 0.788
3oxx DR7Gag-Pol polyprotein 3.4.23.16 0.788
2qi5 MZ7Gag-Pol polyprotein / 0.783
3r4b 74TGag-Pol polyprotein / 0.783
3sa6 F71Protease / 0.780
3sac AF8Protease / 0.780
4j5j 478Gag-Pol polyprotein 3.4.23.16 0.779
2i4w KGQProtease / 0.776
3tl9 ROCGag-Pol polyprotein 3.4.23.16 0.775
4j55 031Gag-Pol polyprotein 3.4.23.16 0.775
1ida 0POGag-Pol polyprotein 3.4.23.47 0.771
1b6l PI4Gag-Pol polyprotein 3.4.23.16 0.768
3saa 77FProtease / 0.768
3s56 ROCProtease / 0.767
3ttp 017Gag-Pol polyprotein 3.4.23.16 0.767
1b6k PI5Gag-Pol polyprotein 3.4.23.16 0.765
2nmy ROCProtease / 0.757
1iiq 0ZRGag-Pol polyprotein 3.4.23.16 0.750
2qi7 MZ9Gag-Pol polyprotein / 0.750
1fgc 2NCGag-Pol polyprotein 3.4.23.16 0.747
4djq M86Pol polyprotein / 0.747
4rvj 478Protease / 0.746
1k6t XN1Gag-Pol polyprotein 3.4.23.16 0.743
3s85 LK0Gag-Pol polyprotein / 0.743
3k4v ROCGag-Pol polyprotein 3.4.23.16 0.741
2a4f AAUV-1 protease / 0.740
2qhz MZ2Gag-Pol polyprotein / 0.740
4qgi ROCGag-Pol polyprotein 3.4.23.16 0.740
3d1y ROCGag-Pol polyprotein 3.4.23.16 0.739
3nu9 478Gag-Pol polyprotein 3.4.23.16 0.738
3nuj 478Gag-Pol polyprotein 3.4.23.16 0.736
2fle AIProtease / 0.735
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.732
2q54 MU1Protease / 0.731
1mrw K57Gag-Pol polyprotein 3.4.23.16 0.729
2aqu DR7Gag-Pol polyprotein 3.4.23.16 0.729
1hvi A77Protease / 0.728
3d1x ROCGag-Pol polyprotein 3.4.23.16 0.728
3el9 DR7Gag-Pol polyprotein 3.4.23.16 0.728
1ohr 1UNV-1 PROTEASE protein / 0.727
2fxe DR7Gag-Pol polyprotein 3.4.23.16 0.727
3bxr DRRGag-Pol polyprotein 3.4.23.16 0.726
1mtr PI6Gag-Pol polyprotein 3.4.23.16 0.725
2qak 1UNGag-Pol polyprotein 3.4.23.16 0.725
1sdt MK1Gag-Pol polyprotein 3.4.23.16 0.722
2psv MUVProtease / 0.722
1npa 3NHGag-Pol polyprotein 3.4.23.16 0.721
1npw LGZGag-Pol polyprotein 3.4.23.16 0.721
1pro A88Gag-Pol polyprotein / 0.721
2pk6 O33V-1 protease / 0.720
2bb9 AKCGag-Pol polyprotein 3.4.23.16 0.717
2nnp ROCProtease / 0.717
3ufn ROCGag-Pol polyprotein / 0.716
3sa5 A69Protease / 0.714
1ajv NMBGag-Pol polyprotein 3.4.23.16 0.713
1hvj A78Gag-Pol polyprotein / 0.712
1k2c 0Q4Gag-Pol polyprotein 3.4.23.16 0.712
3kfr 3TLGag-Pol polyprotein / 0.712
1d4h BEHGag-Pol polyprotein 3.4.23.16 0.711
2i0d MUTProtease / 0.711
1sbg IM1Gag-Pol polyprotein / 0.708
1izh Q50Protease / 0.707
2p3c 3TLProtease / 0.707
3kfn 3TLGag-Pol polyprotein / 0.707
3pwr ROCGag-Pol polyprotein 3.4.23.16 0.707
1siv PSIGag-Pol polyprotein / 0.704
3em4 DR7Gag-Pol polyprotein 3.4.23.16 0.704
1d4i BEGGag-Pol polyprotein 3.4.23.16 0.703
3ekq ROCGag-Pol polyprotein 3.4.23.16 0.702
1fff 0Q4Gag-Pol polyprotein 3.4.23.16 0.701
1fg6 2NCGag-Pol polyprotein 3.4.23.16 0.701
1hii C20Gag-Pol polyprotein / 0.701
3kfs 3TLGag-Pol polyprotein / 0.701
1sdu MK1Gag-Pol polyprotein 3.4.23.16 0.699
3el1 DR7Gag-Pol polyprotein 3.4.23.16 0.699
1jld 0PPGag-Pol polyprotein / 0.696
2bqv A1AProtease / 0.696
1w5x BE5Gag-Pol polyprotein 3.4.23.16 0.694
3cyx ROCGag-Pol polyprotein 3.4.23.16 0.694
1ebz BECGag-Pol polyprotein 3.4.23.16 0.693
3el4 ROCGag-Pol polyprotein 3.4.23.16 0.693
3qrm NK7Gag-Pol polyprotein 3.4.23.16 0.693
3dcr KVSProtease / 0.692
3nwx KVSGag-Pol polyprotein 3.4.23.16 0.691
1tcx IM1Gag-Pol polyprotein 3.4.23.16 0.688
2pym 1UNGag-Pol polyprotein 3.4.23.16 0.687
1a94 0Q4Gag-Pol polyprotein 3.4.23.16 0.686
1w5w BE4Gag-Pol polyprotein 3.4.23.16 0.684
3gga GGWGag-Pol polyprotein / 0.684
3nwq 2NCGag-Pol polyprotein 3.4.23.16 0.684
3slz 3TLPutative gag-pro-pol polyprotein / 0.684
1ec0 BEDGag-Pol polyprotein 3.4.23.16 0.683
1bdr IM1Gag-Pol polyprotein 3.4.23.16 0.682
1kzk JE2Gag-Pol polyprotein 3.4.23.16 0.682
1sdv MK1Gag-Pol polyprotein 3.4.23.16 0.682
3ekp 478Gag-Pol polyprotein 3.4.23.16 0.681
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.679
1ff0 2NCGag-Pol polyprotein 3.4.23.16 0.679
1msn JE2Gag-Pol polyprotein 3.4.23.16 0.679
1w5v BE3Gag-Pol polyprotein 3.4.23.16 0.679
3nls 016Gag-Pol polyprotein 3.4.23.16 0.679
1ffi 2NCGag-Pol polyprotein 3.4.23.16 0.678
2rkf AB1Pol protein / 0.677
2f3k RO1Protease / 0.676
1k2b 0Q4Gag-Pol polyprotein 3.4.23.16 0.675
2nnk ROCProtease / 0.675
1a8g 2Z4Gag-Pol polyprotein 3.4.23.16 0.673
1d4j MSCGag-Pol polyprotein 3.4.23.16 0.672
1fej 2NCGag-Pol polyprotein 3.4.23.16 0.672
1ebw BEIGag-Pol polyprotein 3.4.23.16 0.671
1wbm BLLPol protein / 0.671
2aoe 0Q4Gag-Pol polyprotein 3.4.23.16 0.671
2q63 1UNGag-Pol polyprotein 3.4.23.16 0.670
1dw6 0Q4Gag-Pol polyprotein 3.4.23.16 0.669
1hvr XK2Gag-Pol polyprotein / 0.666
2fxd DR7Pol polyprotein / 0.666
3nxe 2NCProtease / 0.665
2b60 RITPol polyprotein / 0.664
2r3w G3GGag-Pol polyprotein 3.4.23.16 0.664
3ndu ROCGag-Pol polyprotein 3.4.23.16 0.664
1mrx K57Gag-Pol polyprotein 3.4.23.16 0.663
3a2o KNJGag-Pol polyprotein 3.4.23.16 0.663
1bwa XV6Gag-Pol polyprotein 3.4.23.16 0.662
1ec1 BEEGag-Pol polyprotein 3.4.23.16 0.662
1qbt 146Gag-Pol polyprotein 3.4.23.16 0.661
3bgb LJGGag-Pol polyprotein 3.4.23.16 0.661
4fe6 0TQGag-Pol polyprotein 3.4.23.16 0.660
2qnp QN2Gag-Pol polyprotein 3.4.23.16 0.658
2wl0 5AHGag-Pol polyprotein / 0.658
1bv7 XV6Gag-Pol polyprotein 3.4.23.16 0.657
2a1e IPFGag-Pol polyprotein 3.4.23.16 0.657
1hsg MK1Gag-Pol polyprotein / 0.656
3qrs NK8Gag-Pol polyprotein 3.4.23.16 0.656
1eag A70Candidapepsin-2 3.4.23.24 0.655
2xye CXGGag-Pol polyprotein / 0.655
3nyg 2NCGag-Pol polyprotein 3.4.23.16 0.655
1c6x 3INProtease / 0.654
1fg8 0Q4Gag-Pol polyprotein 3.4.23.16 0.654
2avm 2NCGag-Pol polyprotein 3.4.23.16 0.654
3ckt YDPGag-Pol polyprotein 3.4.23.16 0.654
3jvw DMPGag-Pol polyprotein 3.4.23.16 0.654
1hwr 216Gag-Pol polyprotein 3.4.23.16 0.653
1msm JE2Gag-Pol polyprotein 3.4.23.16 0.653
3ekw DR7Gag-Pol polyprotein 3.4.23.16 0.653
1hvl A76Gag-Pol polyprotein / 0.652
2r3t G4GGag-Pol polyprotein 3.4.23.16 0.652
3liq E14Protease / 0.652
4a6b QG8Gag-Pol polyprotein 3.4.23.16 0.652
1ec3 MS3Gag-Pol polyprotein 3.4.23.16 0.651
1g35 AHFGag-Pol polyprotein 3.4.23.16 0.651
1hos PHPGag-Pol polyprotein / 0.650
1idb 0DOGag-Pol polyprotein / 0.650
3zpu M8BGag-Pol polyprotein 3.4.23.16 0.650