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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dbq NAP Glyoxylate reductase 1.1.1.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dbq NAPGlyoxylate reductase 1.1.1.26 1.199
2dbr NAPGlyoxylate reductase 1.1.1.26 0.990
2dbz NAPGlyoxylate reductase 1.1.1.26 0.879
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.831
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.736
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.725
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.725
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.720
4weq NAPNAD-dependent dehydrogenase / 0.719
2nad NADFormate dehydrogenase / 0.715
3kb6 NADD-lactate dehydrogenase / 0.715
1zh8 NAPUncharacterized protein / 0.707
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.706
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.706
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.689
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.689
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.687
4z0p NDPNAD-dependent dehydrogenase / 0.682
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.681
2dc1 NADProbable L-aspartate dehydrogenase / 0.675
4xye NADFormate dehydrogenase / 0.674
1xcb NADRedox-sensing transcriptional repressor Rex / 0.668
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.668
2gsd NADFormate dehydrogenase / 0.663
2wzv FMNNitroreductase NfnB / 0.662
2wzw FMNNitroreductase NfnB / 0.662
3ptz NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.662
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.660
4j43 NADUncharacterized protein / 0.660
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.658
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.651
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.651
5j23 A2RPutative 2-hydroxyacid dehydrogenase / 0.651
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.650