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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c1a I5S cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.083
2jdt I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.852
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.825
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.801
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2gni M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.713
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
1q8w M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.691
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.690
1svh I08cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.688
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.674
2gu8 796cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2f7x 4EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.661
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
4agu D15Cyclin-dependent kinase-like 1 / 0.658
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.656
2vag V25Dual specificity protein kinase CLK1 2.7.12.1 0.654
2x6d X6DAurora kinase A 2.7.11.1 0.653
3bhy 7CPDeath-associated protein kinase 3 / 0.653
2cke IQUDeath-associated protein kinase 2 / 0.652
4elb 34SDihydrofolate reductase / 0.651
1rek B8LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
3ma3 01ISerine/threonine-protein kinase pim-1 2.7.11.1 0.650