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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2brb PFQ Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2brb PFQSerine/threonine-protein kinase Chk1 2.7.11.1 0.836
2brm DFZSerine/threonine-protein kinase Chk1 2.7.11.1 0.803
2bro DF2Serine/threonine-protein kinase Chk1 2.7.11.1 0.783
2br1 PFPSerine/threonine-protein kinase Chk1 2.7.11.1 0.766
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
2brh DFWSerine/threonine-protein kinase Chk1 2.7.11.1 0.703
2brg DFYSerine/threonine-protein kinase Chk1 2.7.11.1 0.686
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.672
2brn DF1Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4jbp YPHAurora kinase A 2.7.11.1 0.656