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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aou CQA Histamine N-methyltransferase 2.1.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aou CQAHistamine N-methyltransferase 2.1.1.8 0.790
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
3rzp PRFNADPH-dependent 7-cyano-7-deazaguanine reductase / 0.744
3uxv GUNNADPH-dependent 7-cyano-7-deazaguanine reductase / 0.744
4iok ADPFormate--tetrahydrofolate ligase / 0.744
4jjz ADPFormate--tetrahydrofolate ligase / 0.744
4y8v ADPAcyl-CoA synthetase (NDP forming) / 0.744
1wet GUNHTH-type transcriptional repressor PurR / 0.660
2jey HLOAcetylcholinesterase 3.1.1.7 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
2puf GUNHTH-type transcriptional repressor PurR / 0.660
4hrq AZGCytidine and deoxycytidylate deaminase zinc-binding region / 0.660