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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aa5 STR Mineralocorticoid receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2aa5 STRMineralocorticoid receptor / 1.100
2aa6 STRMineralocorticoid receptor / 1.015
2aa7 1CAMineralocorticoid receptor / 0.989
2ab2 SNLMineralocorticoid receptor / 0.902
2a3i C0RMineralocorticoid receptor / 0.901
1ya3 STRMineralocorticoid receptor / 0.768
3mnp DEXGlucocorticoid receptor / 0.748
2oax SNLMineralocorticoid receptor / 0.747
2abi 1CAMineralocorticoid receptor / 0.741
4p6x HCYGlucocorticoid receptor / 0.737
1sqn NDRProgesterone receptor / 0.712
4udc DEXGlucocorticoid receptor / 0.711
3d90 NOGProgesterone receptor / 0.710
4pxm ESTEstrogen receptor / 0.708
3vhu SNLMineralocorticoid receptor / 0.703
2aba STRPentaerythritol tetranitrate reductase / 0.699
5hyr ESTEstrogen receptor / 0.699
4uda DEXMineralocorticoid receptor / 0.698
1gwr ESTEstrogen receptor / 0.696
3gkj HC3Niemann-Pick C1 protein / 0.696
3s79 ASDAromatase 1.14.14.14 0.696
1p93 DEXGlucocorticoid receptor / 0.693
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.692
2qgt EEDEstrogen receptor / 0.686
3eqm ASDAromatase 1.14.14.14 0.686
2qo5 CHDFatty acid-binding protein 10-A, liver basic / 0.684
4q0a 4OAVitamin D3 receptor A / 0.684
2j7x ESTEstrogen receptor beta / 0.680
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.679
3w5p 4OAVitamin D3 receptor / 0.679
1o1v TCHGastrotropin / 0.677
2yja ESTEstrogen receptor / 0.676
2b1z 17MEstrogen receptor / 0.675
2aa2 AS4Mineralocorticoid receptor / 0.673
4a84 DXCMajor pollen allergen Bet v 1-A / 0.673
1m2z DEXGlucocorticoid receptor / 0.670
5dx3 ESTEstrogen receptor / 0.668
2yat EEUEstrogen receptor / 0.666
2q9f C3SCholesterol 24-hydroxylase / 0.665
4e5f 0N7Polymerase acidic protein / 0.665
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.662
2ft9 CHDFatty acid-binding protein 2, liver / 0.661
3k9v CPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial / 0.661
3mno DEXGlucocorticoid receptor / 0.661
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.660
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
3uud ESTEstrogen receptor / 0.656
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.654
3oll ESTEstrogen receptor beta / 0.653
4bqu CLRJapanin / 0.652
2ovm AS0Progesterone receptor / 0.651