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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z9a NAD NAD(P)H-dependent D-xylose reductase 1.1.1.307

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.342
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.252
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.147
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.038
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.954
1ah4 NAPAldose reductase 1.1.1.21 0.864
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.858
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.852
4l1x NAPAldo-keto reductase family 1 member C2 / 0.810
3wg6 NDPNADPH-dependent conjugated polyketone reductase C1 / 0.807
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.803
1s1r NAPAldo-keto reductase family 1 member C3 / 0.802
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 0.802
3ln3 NADAldo-keto reductase family 1 member C13 / 0.791
3h7r NAPAldo-keto reductase family 4 member C8 / 0.786
1x96 NAPAldose reductase 1.1.1.21 0.783
4jtq NAPAldo-keto reductase family 1 member C2 / 0.781
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.780
2hdj NDPAldo-keto reductase family 1 member C2 / 0.778
1s1p NAPAldo-keto reductase family 1 member C3 / 0.773
4g5d NDPProstaglandin F synthase 1.1.1.188 0.771
2j8t NAPAldose reductase 1.1.1.21 0.766
3v36 NAPAldose reductase 1.1.1.21 0.765
1x98 NAPAldose reductase 1.1.1.21 0.763
2pev NDPAldose reductase 1.1.1.21 0.756
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.755
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.754
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.754
2acs NAPAldose reductase 1.1.1.21 0.753
2pf8 NDPAldose reductase 1.1.1.21 0.752
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.752
1ads NAPAldose reductase 1.1.1.21 0.750
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.750
1z8a NAPAldose reductase 1.1.1.21 0.748
2acu NAPAldose reductase 1.1.1.21 0.746
3q67 NAPAldose reductase 1.1.1.21 0.746
4pmj NAPPutative oxidoreductase / 0.746
2vdg NDPAldose reductase 1.1.1.21 0.742
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.742
2bgs NDPAldose reductase 1.1.1.21 0.740
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.736
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.734
5c7h NDPPutative oxidoreductase / 0.731
3o3r NAPAldose reductase-related protein 1 1.1.1.21 0.719
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.719
2acq NAPAldose reductase 1.1.1.21 0.714
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.713
1ef3 NAPAldose reductase 1.1.1.21 0.710
3wcz NAPAldo-keto reductase AKR2E4 / 0.708
2iq0 NAPAldose reductase 1.1.1.21 0.704
2pfh NDPAldose reductase 1.1.1.21 0.703
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.699
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.699
3qkz NAPAldose reductase-related protein 1 1.1.1.21 0.699
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 0.698
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.697
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.695
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.694
1pz0 NAPProtein IolS 1.1.1 0.689
1lqa NDPProtein tas / 0.685
1og6 NAPOxidoreductase YdhF 1 0.683
3q65 NAPAldose reductase 1.1.1.21 0.679
1lwi NAP3-alpha-hydroxysteroid dehydrogenase 1.1.1.50 0.675
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.675
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.673
1az2 NAPAldose reductase 1.1.1.21 0.671
1zgd NAPChalcone reductase / 0.670
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.666
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.653