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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yb1 AOI Estradiol 17-beta-dehydrogenase 11 1.1.1.62

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1yb1 AOIEstradiol 17-beta-dehydrogenase 11 1.1.1.62 0.946
4oed DHTAndrogen receptor / 0.681
1t5z DHTAndrogen receptor / 0.678
2q7l TESAndrogen receptor / 0.677
2q7k TESAndrogen receptor / 0.672
3w5r LOAVitamin D3 receptor / 0.671
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.666
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.664
4jbt ASDCytochrome P450 monooxygenase / 0.663
2qpy DHTAndrogen receptor / 0.661
3w5p 4OAVitamin D3 receptor / 0.661
4q0a 4OAVitamin D3 receptor A / 0.661
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
4e5l DBHPolymerase acidic protein / 0.660
5dx3 ESTEstrogen receptor / 0.658
2q7j TESAndrogen receptor / 0.657
2am9 TESAndrogen receptor / 0.656
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.654
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
4e5f 0N7Polymerase acidic protein / 0.653
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
2pnj CHDFerrochelatase, mitochondrial 4.99.1.1 0.652
1t63 DHTAndrogen receptor / 0.651
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.651
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.650
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.650