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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1uxn NAP NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.380
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.312
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.270
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.201
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.189
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 1.147
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.957
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.910
3b4w NADAldehyde dehydrogenase family protein / 0.876
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.875
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.869
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.866
2jg7 NADAntiquitin / 0.865
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.863
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.858
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.845
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.838
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.828
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.820
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.817
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.816
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.807
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.805
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.803
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.801
4pz2 NADAldehyde dehydrogenase 2-6 / 0.796
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.794
4i8p NADAminoaldehyde dehydrogenase 1 / 0.791
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.783
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.780
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.780
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.771
3haz NADBifunctional protein PutA / 0.763
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.762
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.758
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.756
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.754
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.749
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.747
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.746
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.737
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.737
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.729
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.728
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.716
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.710
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.706
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.705
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.691
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.679
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.679
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.678
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.674
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.671
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.671
4pxl NADAldehyde dehydrogenase3 / 0.669
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.666
4i8q NADPutative betaine aldehyde dehyrogenase / 0.665
4i3v NADAldehyde dehydrogenase (NAD+) / 0.664
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.663
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.662
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.659
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.658
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.656
4c3s NADAldehyde Dehydrogenase / 0.653
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.652
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.651
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.651
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.650