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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tiq COA Spermidine/spermine N(1)-acetyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tiq COASpermidine/spermine N(1)-acetyltransferase / 1.762
2cy2 ACOProbable acetyltransferase / 0.887
3exn ACOProbable acetyltransferase / 0.848
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.832
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.831
4ua3 COAN-alpha-acetyltransferase 40 2.3.1 0.831
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.823
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.810
3vwd ACOAlpha-tubulin N-acetyltransferase 1 / 0.802
1wwz ACOUncharacterized protein / 0.798
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.792
4u9y COAAlpha-tubulin N-acetyltransferase 1 / 0.791
2ozu ACOHistone acetyltransferase KAT6A / 0.781
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.766
2b3v ACODiamine acetyltransferase 1 / 0.765
1fy7 COAHistone acetyltransferase ESA1 / 0.751
1qsm ACOHistone acetyltransferase HPA2 / 0.751
1mjb ACOHistone acetyltransferase ESA1 / 0.749
2fxf ACODiamine acetyltransferase 1 / 0.743
3bj7 COADiamine acetyltransferase 1 / 0.743
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.741
5kgh ACOPredicted acetyltransferase / 0.740
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.739
5kf2 ACOPredicted acetyltransferase / 0.739
5kgp ACOPredicted acetyltransferase / 0.739
1mja COAHistone acetyltransferase ESA1 / 0.738
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.738
4kub COAUncharacterized protein / 0.736
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.736
5kf8 ACOPredicted acetyltransferase / 0.736
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.734
1bob ACOHistone acetyltransferase type B catalytic subunit / 0.733
2a4n COAAac(6')-Ii protein / 0.732
2vqy ACOAAC(6')-Ib / 0.732
1pu9 COAHAT A1 / 0.731
1kuy COTSerotonin N-acetyltransferase / 0.730
1n71 COAAac(6')-Ii protein / 0.727
5kf1 ACOPredicted acetyltransferase / 0.727
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.726
1j4j ACOAcetyltransferase 2.3.1 0.725
3f0a ACOSpermidine N(1)-acetyltransferase / 0.720
4ava ACOAcetyltransferase Pat 2.3.1 0.720
3gy9 COAGCN5-related N-acetyltransferase / 0.716
3k9u ACOSpermidine N(1)-acetyltransferase / 0.716
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.715
2cns ACORibosomal-protein-alanine acetyltransferase / 0.715
3r95 ACOMccE protein / 0.712
3zj0 ACOPutative acetyltransferase OgpAT / 0.712
5kgj ACOPredicted acetyltransferase / 0.710
2bue COAAAC(6')-Ib / 0.708
5kf9 ACOPredicted acetyltransferase / 0.707
1qsr ACOHAT A1 / 0.699
3r96 ACOMccE protein / 0.697
5kf9 COAPredicted acetyltransferase / 0.697
2ou2 ACOHistone acetyltransferase KAT5 / 0.696
3gya COAGCN5-related N-acetyltransferase / 0.696
4gs4 ACOAlpha-tubulin N-acetyltransferase 1 / 0.696
5kf8 COAPredicted acetyltransferase / 0.694
2y0m ACOHistone acetyltransferase KAT8 / 0.693
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.691
1b87 ACOAac(6')-Ii protein / 0.687
1pua COAHAT A1 / 0.687
1cjw COTSerotonin N-acetyltransferase / 0.683
4b5p ACOAlpha-tubulin N-acetyltransferase 1 / 0.682
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.682
2bsw CAOProbable acetyltransferase / 0.681
2jdd ACOProbable acetyltransferase / 0.681
3cz7 ACOHistone acetyltransferase RTT109 2.3.1.48 0.681
4jxr ACOAcetyltransferase / 0.681
1ib1 COTSerotonin N-acetyltransferase / 0.678
4u9z COAAlpha-tubulin N-acetyltransferase 1 / 0.678
1ghe ACOAcetyltransferase 2.3.1 0.677
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.676
4r3k COAN-alpha-acetyltransferase 2.3.1 0.676
5kf2 COAPredicted acetyltransferase / 0.676
1s7n COAAcetyl transferase / 0.674
3te4 ACODopamine N-acetyltransferase / 0.673
1qsn COAHAT A1 / 0.671
1v0c ACOAAC(6')-Ib / 0.671
4jwp ACOGCN5-related N-acetyltransferase / 0.670
5kf1 COAPredicted acetyltransferase / 0.667
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.665
3pgp ACOUncharacterized protein / 0.662
4kvm SER_ALA_SER_GLU_1XEN-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.661
2x7b COAN-alpha-acetyltransferase 2.3.1 0.659
2zfn ACOHistone acetyltransferase RTT109 2.3.1.48 0.659
1m1d LYXHAT A1 / 0.658
2cnt COARibosomal-protein-alanine acetyltransferase / 0.657
2rc4 ACOHistone acetyltransferase KAT6A / 0.657
2giv ACOHistone acetyltransferase KAT8 / 0.654
1mj9 COAHistone acetyltransferase ESA1 / 0.653
1m4i COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.652
2r8v ACOAmino-acid acetyltransferase / 0.652
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.652
4a2z MYAGlycylpeptide N-tetradecanoyltransferase / 0.651