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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t36 ADP Carbamoyl-phosphate synthase large chain

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.917
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.782
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.739
4gyi ADPUncharacterized protein / 0.711
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.710
4ffr ATPUncharacterized protein / 0.710
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.702
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.700
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.697
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.696
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.696
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.696
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.694
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.692
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.692
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.692
5ce3 ADPProtein kinase YopO / 0.691
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.690
4xlv ACPInsulin receptor 2.7.10.1 0.690
2pui ADPMethylthioribose kinase 2.7.1.100 0.688
3pff ADPATP-citrate synthase 2.3.3.8 0.688
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.688
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.687
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.684
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.684
1px2 ATPSynapsin-1 / 0.683
3bu5 ATPInsulin receptor 2.7.10.1 0.683
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.682
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.681
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.680
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.676
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.674
3qc9 ADPRhodopsin kinase / 0.674
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1m0w ANPGlutathione synthetase 6.3.2.3 0.672
4ffl ADPUncharacterized protein / 0.671
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.670
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.670
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.668
3tw6 ADPPyruvate carboxylase / 0.667
2pyw ADPMethylthioribose kinase 2.7.1.100 0.666
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.666
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.666
4ysj ADPCalmodulin-like domain protein kinase / 0.666
4ffm ADPUncharacterized protein / 0.665
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
3g8d ADPBiotin carboxylase 6.3.4.14 0.664
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.664
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.664
5c1p ADPD-alanine--D-alanine ligase / 0.663
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.661
5dos ATPAurora kinase A 2.7.11.1 0.661
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.660
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.660
3c4z ADPRhodopsin kinase / 0.660
3wo0 ADPAlanine--anticapsin ligase / 0.660
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.658
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3llt ANPProtein serine/threonine kinase-1 / 0.657
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.657
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.657
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.657
5dr2 ATPAurora kinase A 2.7.11.1 0.657
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.656
3wo1 ADPAlanine--anticapsin ligase / 0.656
5bpf ADPD-alanine--D-alanine ligase / 0.656
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.655
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.655
3c50 ADPRhodopsin kinase / 0.654
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.654
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.653
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.652
4dee ADPAurora kinase A 2.7.11.1 0.650
5dt3 ATPAurora kinase A 2.7.11.1 0.650