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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1sqn NDR Progesterone receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1sqn NDRProgesterone receptor / 1.123
3d90 NOGProgesterone receptor / 1.008
4a2j AS0Progesterone receptor / 0.867
2w8y NDRProgesterone receptor / 0.854
3vhu SNLMineralocorticoid receptor / 0.808
2aa7 1CAMineralocorticoid receptor / 0.763
2abi 1CAMineralocorticoid receptor / 0.745
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
2oax SNLMineralocorticoid receptor / 0.740
2aa6 STRMineralocorticoid receptor / 0.736
2ab2 SNLMineralocorticoid receptor / 0.736
5hyr ESTEstrogen receptor / 0.725
2ovm AS0Progesterone receptor / 0.717
2aa5 STRMineralocorticoid receptor / 0.712
3w5q 3KLVitamin D3 receptor / 0.710
1t7r DHTAndrogen receptor / 0.709
1gwr ESTEstrogen receptor / 0.707
1y9r 1CAMineralocorticoid receptor / 0.704
2a3i C0RMineralocorticoid receptor / 0.700
2ao6 R18Androgen receptor / 0.697
2aax PDNMineralocorticoid receptor / 0.696
1xow R18Androgen receptor / 0.695
4ofr DHTAndrogen receptor / 0.695
1t7t DHTAndrogen receptor / 0.690
3w5p 4OAVitamin D3 receptor / 0.688
5dxg ESTEstrogen receptor / 0.682
2j7x ESTEstrogen receptor beta / 0.679
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.677
2q7l TESAndrogen receptor / 0.674
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.674
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.668
3uud ESTEstrogen receptor / 0.668
1nhz 486Glucocorticoid receptor / 0.664
2yat EEUEstrogen receptor / 0.663
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1t5z DHTAndrogen receptor / 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4oey DHTAndrogen receptor / 0.660
1xq3 R18Androgen receptor / 0.659
2pit DHTAndrogen receptor / 0.657
1f5f DHTSex hormone-binding globulin / 0.655
3q95 ESLEstrogen receptor / 0.655
2ama DHTAndrogen receptor / 0.651
4uda DEXMineralocorticoid receptor / 0.650