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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1p72 THM Thymidine kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1p72 THMThymidine kinase / 0.992
1p6x THMThymidine kinase / 0.947
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2vp0 TTPDeoxynucleoside kinase / 0.734
1zm7 TTPDeoxynucleoside kinase / 0.719
2jcs TTPDeoxynucleoside kinase / 0.711
2jj8 AZZDeoxynucleoside kinase / 0.683
1oe0 TTPDeoxynucleoside kinase / 0.676
2ixk TDOdTDP-4-dehydrorhamnose 3,5-epimerase 5.1.3.13 0.676
1n5i TMPThymidylate kinase 2.7.4.9 0.675
2uz3 TTPThymidine kinase / 0.674
1ot3 THMDeoxynucleoside kinase / 0.672
5fuv THMThymidine kinase, putative / 0.669
3khu UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.665
2b8t THMThymidine kinase / 0.662
4e5f 0N7Polymerase acidic protein / 0.660
1e2j THMThymidine kinase / 0.655
1w2g THMThymidylate kinase 2.7.4.9 0.655
4jbx SK7Thymidine kinase / 0.655
2wvj TTPThymidine kinase, cytosolic 2.7.1.21 0.654
3ryk TYDdTDP-4-dehydrorhamnose 3,5-epimerase / 0.654