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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ol7 ADP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ol7 ADPAurora kinase A 2.7.11.1 0.890
1ol5 ADPAurora kinase A 2.7.11.1 0.777
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.756
4dee ADPAurora kinase A 2.7.11.1 0.731
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.724
4bn1 ADPAurora kinase A 2.7.11.1 0.723
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.719
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.712
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.708
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.703
5dos ATPAurora kinase A 2.7.11.1 0.703
4utd ACPAurora kinase A 2.7.11.1 0.699
4ceg ADPAurora kinase A 2.7.11.1 0.696
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.696
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.692
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.691
2dwb ANPAurora kinase A 2.7.11.1 0.689
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.688
2olc ADPMethylthioribose kinase 2.7.1.100 0.686
5dr2 ATPAurora kinase A 2.7.11.1 0.686
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.685
5dnr ATPAurora kinase A 2.7.11.1 0.685
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.683
5dt3 ATPAurora kinase A 2.7.11.1 0.682
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3cly ACPFibroblast growth factor receptor 2 / 0.681
4qny ANPMitogen activated protein kinase, putative / 0.681
1mq4 ADPAurora kinase A 2.7.11.1 0.677
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.677
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
2pml ANPUncharacterized protein / 0.675
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.675
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.674
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.672
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.672
5dt4 ATPAurora kinase A 2.7.11.1 0.672
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.670
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.668
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.667
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.667
5drd ATPAurora kinase A 2.7.11.1 0.667
5dn3 ATPAurora kinase A 2.7.11.1 0.666
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.665
5l6w AGSLIM domain kinase 1 2.7.11.1 0.665
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
4gyi ADPUncharacterized protein / 0.663
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.662
4o1p ANPRibonuclease L / 0.662
3c50 ADPRhodopsin kinase / 0.661
3r5f ATPD-alanine--D-alanine ligase / 0.661
4bis 8HQLysine-specific demethylase 4A 1.14.11 0.661
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.661
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4zgn ATPCell division cycle protein 123 / 0.660
5d4g U5PPolymerase acidic protein / 0.660
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
5ccy TMPPolymerase acidic protein / 0.659
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.658
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.658
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
3c4w ATPRhodopsin kinase / 0.657
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3c4x ATPRhodopsin kinase / 0.655
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.655
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.654
2pul ACPMethylthioribose kinase 2.7.1.100 0.653
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.653
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.653
4o4f ATPKinase / 0.653
2pun ACPMethylthioribose kinase 2.7.1.100 0.652
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.651
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.650
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.650
5ce3 ADPProtein kinase YopO / 0.650