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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1oit HDT Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.912
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.750
3r9o Z71Cyclin-dependent kinase 2 2.7.11.22 0.739
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.739
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.733
1oiq HDUCyclin-dependent kinase 2 2.7.11.22 0.714
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.703
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.702
2w05 FRTCyclin-dependent kinase 2 2.7.11.22 0.700
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.695
3r9h Z67Cyclin-dependent kinase 2 2.7.11.22 0.695
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.688
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.687
3nup 3NUCyclin-dependent kinase 6 2.7.11.22 0.684
4ez3 0S0Cyclin-dependent kinase 2 2.7.11.22 0.684
2w17 I19Cyclin-dependent kinase 2 2.7.11.22 0.683
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.682
2c6t DT5Cyclin-dependent kinase 2 2.7.11.22 0.681
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.681
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.680
2fvd LIACyclin-dependent kinase 2 2.7.11.22 0.679
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.674
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.674
2c6k DT2Cyclin-dependent kinase 2 2.7.11.22 0.673
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.670
4bcn T9NCyclin-dependent kinase 2 2.7.11.22 0.668
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.667
1v1k 3FPCyclin-dependent kinase 2 2.7.11.22 0.666
2np8 CC3Aurora kinase A 2.7.11.1 0.665
2uzl C94Cyclin-dependent kinase 2 2.7.11.22 0.665
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.664
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.664
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.663
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.662
3qxp X64Cyclin-dependent kinase 2 2.7.11.22 0.662
2euf LQQCyclin-dependent kinase 6 2.7.11.22 0.661
4eor 4SPCyclin-dependent kinase 2 2.7.11.22 0.660
4dea NHIAurora kinase A 2.7.11.1 0.659
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.658
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.658
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.657
2uzo C62Cyclin-dependent kinase 2 2.7.11.22 0.657
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.657
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.657
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.657
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.652
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.651
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.651
1y8y CT7Cyclin-dependent kinase 2 2.7.11.22 0.650
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.650