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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ny3 ADP MAP kinase-activated protein kinase 2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.840
4ax8 ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.703
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.701
3b2t M33Fibroblast growth factor receptor 2 / 0.701
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.701
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.688
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.686
4dt8 ADNAPH(2'')-Id / 0.685
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
2olc ADPMethylthioribose kinase 2.7.1.100 0.678
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.675
2pui ADPMethylthioribose kinase 2.7.1.100 0.671
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.670
4n57 ADPAPH(2'')-Id / 0.669
2pun ACPMethylthioribose kinase 2.7.1.100 0.668
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.664
2wqe ADPAurora kinase A 2.7.11.1 0.664
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.662
3zo4 QWIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4mv3 ACPBiotin carboxylase 6.3.4.14 0.661
4fic 0ULProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.659
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.659
2pul ACPMethylthioribose kinase 2.7.1.100 0.658
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.657
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.656
3p23 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.656
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.655
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.652
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.651
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.651
4o0w ADNAurora kinase A 2.7.11.1 0.651
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.651
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.650
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.650
4j98 ACPFibroblast growth factor receptor 2 / 0.650