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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nvq UCN Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 1.250
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 1.118
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 1.010
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.894
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.893
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.883
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.864
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.845
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.837
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.822
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.813
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.808
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.784
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.782
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.780
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.780
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.779
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.771
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.770
1byg STUTyrosine-protein kinase CSK / 0.753
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.753
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.749
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.738
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.737
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.737
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.736
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.731
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.728
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.712
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.709
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.701
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
1xjd STUProtein kinase C theta type 2.7.11.13 0.695
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.674
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.671
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.669
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.668
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.667
4fny I3KALK tyrosine kinase receptor 2.7.10.1 0.665
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.663
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1uu3 LY43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2yer TQ1Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.656
2z2w 770Wee1-like protein kinase 2.7.10.2 0.655
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.654
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.653
3r9d X6BCyclin-dependent kinase 2 2.7.11.22 0.651