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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1n2g APC Pantothenate synthetase 6.3.2.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1n2g APCPantothenate synthetase 6.3.2.1 1.141
1n2e APCPantothenate synthetase 6.3.2.1 1.113
2a84 ATPPantothenate synthetase 6.3.2.1 0.906
3iob A4DPantothenate synthetase 6.3.2.1 0.789
3coz 54HPantothenate synthetase 6.3.2.1 0.773
3coy 53HPantothenate synthetase 6.3.2.1 0.771
3iod A6DPantothenate synthetase 6.3.2.1 0.768
3ioc A5DPantothenate synthetase 6.3.2.1 0.758
3ioe A7DPantothenate synthetase 6.3.2.1 0.736
3qtt ANPPantothenate synthetase / 0.727
3ag6 PAJPantothenate synthetase / 0.711
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.686
2x3f APCPantothenate synthetase / 0.686
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.682
5hg0 SAMPantothenate synthetase / 0.682
4fvr ATPTyrosine-protein kinase JAK2 / 0.680
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.670
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.668
5i4n ATPTyrosine-protein kinase JAK2 / 0.666
1p3d UMAUDP-N-acetylmuramate--L-alanine ligase 6.3.2.8 0.663
4x3m ADNRNA 2'-O ribose methyltransferase / 0.663
3qbt GNPRas-related protein Rab-8A / 0.661
3kt3 TYMTryptophan--tRNA ligase, cytoplasmic 6.1.1.2 0.660
5erm 210Fusicoccadiene synthase 4.2.3.43 0.660
3i5x ANPATP-dependent RNA helicase MSS116, mitochondrial 3.6.4.13 0.657
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.657
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.657
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.655
1svw GTPProbable GTP-binding protein EngB / 0.654
1xje TTPVitamin B12-dependent ribonucleotide reductase / 0.654
1xs4 DCPdCTP deaminase / 0.654
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.654
3zxi TYATyrosine--tRNA ligase, mitochondrial 6.1.1.1 0.652
2wow NDPTrypanothione reductase / 0.651