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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1l0c COT Serotonin N-acetyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1l0c COTSerotonin N-acetyltransferase / 1.524
1kuv CA5Serotonin N-acetyltransferase / 1.318
1cjw COTSerotonin N-acetyltransferase / 1.232
1kuy COTSerotonin N-acetyltransferase / 1.206
1ib1 COTSerotonin N-acetyltransferase / 1.075
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.821
5kf2 ACOPredicted acetyltransferase / 0.806
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.804
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.801
1pu9 COAHAT A1 / 0.799
5kf9 ACOPredicted acetyltransferase / 0.797
5kf1 ACOPredicted acetyltransferase / 0.794
5kgj ACOPredicted acetyltransferase / 0.793
2cns ACORibosomal-protein-alanine acetyltransferase / 0.791
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.790
5kgp ACOPredicted acetyltransferase / 0.790
5kf8 ACOPredicted acetyltransferase / 0.785
4r3k COAN-alpha-acetyltransferase 2.3.1 0.782
2x7b COAN-alpha-acetyltransferase 2.3.1 0.781
1kux CA3Serotonin N-acetyltransferase / 0.777
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.775
1qsn COAHAT A1 / 0.763
2cnt COARibosomal-protein-alanine acetyltransferase / 0.762
5kf1 COAPredicted acetyltransferase / 0.762
1j4j ACOAcetyltransferase 2.3.1 0.760
3s6f COAUncharacterized protein / 0.759
4jwp ACOGCN5-related N-acetyltransferase / 0.759
1s5k COAAminoglycoside N(6')-acetyltransferase type 1 / 0.758
3te4 ACODopamine N-acetyltransferase / 0.756
2a4n COAAac(6')-Ii protein / 0.755
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.749
1pua COAHAT A1 / 0.747
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.746
1ghe ACOAcetyltransferase 2.3.1 0.743
2rc4 ACOHistone acetyltransferase KAT6A / 0.742
1bob ACOHistone acetyltransferase type B catalytic subunit / 0.737
2vqy ACOAAC(6')-Ib / 0.737
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.736
5kgh ACOPredicted acetyltransferase / 0.734
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.733
2r8v ACOAmino-acid acetyltransferase / 0.732
3bj7 COADiamine acetyltransferase 1 / 0.732
1qsm ACOHistone acetyltransferase HPA2 / 0.731
2b3v ACODiamine acetyltransferase 1 / 0.728
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.728
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.726
1v0c ACOAAC(6')-Ib / 0.724
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.724
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.723
4qvt ACOAcetyltransferase YpeA 2.3.1 0.723
3f8k COAUncharacterized protein / 0.722
1wwz ACOUncharacterized protein / 0.721
4if5 ACOAlpha-tubulin N-acetyltransferase 1 / 0.720
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.716
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.716
1m4i COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.715
1m1d LYXHAT A1 / 0.714
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.713
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.710
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.709
3exn ACOProbable acetyltransferase / 0.708
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.708
1m4d COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.700
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.699
5kf8 COAPredicted acetyltransferase / 0.696
2psw COAN-alpha-acetyltransferase 50 / 0.692
4kvm SER_ALA_SER_GLU_1XEN-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.691
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.689
3zj0 ACOPutative acetyltransferase OgpAT / 0.689
3r95 ACOMccE protein / 0.685
4ava ACOAcetyltransferase Pat 2.3.1 0.685
2y0m ACOHistone acetyltransferase KAT8 / 0.682
2ozg COAGCN5-related N-acetyltransferase / 0.679
1n71 COAAac(6')-Ii protein / 0.678
3r96 ACOMccE protein / 0.678
3pgp ACOUncharacterized protein / 0.677
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.676
3biy 01KHistone acetyltransferase p300 / 0.676
1s60 COAAminoglycoside N(6')-acetyltransferase type 1 / 0.674
2bue COAAAC(6')-Ib / 0.674
5kf2 COAPredicted acetyltransferase / 0.674
2qir COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.671
5ag7 MYAGlycylpeptide N-tetradecanoyltransferase / 0.671
1b87 ACOAac(6')-Ii protein / 0.670
4bhw 01KHistone acetyltransferase p300 / 0.669
2o28 COAGlucosamine 6-phosphate N-acetyltransferase / 0.667
3d2m COAAmino-acid acetyltransferase / 0.666
1qsr ACOHAT A1 / 0.664
2cy2 ACOProbable acetyltransferase / 0.661
2jdc CAOProbable acetyltransferase / 0.661
1s7n COAAcetyl transferase / 0.659
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.655
5c88 COAN-alpha-acetyltransferase / 0.654
5kf9 COAPredicted acetyltransferase / 0.654
3bj8 COADiamine acetyltransferase 1 / 0.653
2fxf ACODiamine acetyltransferase 1 / 0.650
3ryo ACON-acetyltransferase Eis / 0.650