sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1hdo | NAP | Flavin reductase (NADPH) |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 1hdo | NAP | Flavin reductase (NADPH) | / | 1.455 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.763 | |
| 3e8x | NAP | BH1520 protein | / | 0.743 | |
| 3pdu | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.730 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.729 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.728 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.721 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.720 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.720 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.718 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.718 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.710 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.710 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.707 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.707 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.702 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.700 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.693 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.693 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.692 | |
| 4u7w | NDP | MxaA | / | 0.691 | |
| 1sny | NAP | LD36273p | / | 0.690 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.689 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.683 | |
| 2hk9 | ATR | Shikimate dehydrogenase (NADP(+)) | / | 0.681 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.680 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.677 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.677 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.674 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.674 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.674 | |
| 2iyp | A2P | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.673 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.673 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.673 | |
| 4z0p | NDP | NAD-dependent dehydrogenase | / | 0.672 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.671 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.670 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.665 | |
| 2zzc | NAP | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.665 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.665 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.664 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.663 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.663 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.663 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.661 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.660 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.660 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.660 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.660 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.659 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.659 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.659 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.659 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.658 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.658 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.658 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.657 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.657 | |
| 3s5w | NAP | L-ornithine N(5)-monooxygenase | / | 0.657 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.657 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.655 | |
| 4kwh | NAP | Reductase homolog | / | 0.655 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.654 | |
| 4cbq | NDP | Thioredoxin reductase | / | 0.654 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.654 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.653 | |
| 4qec | NAP | ElxO | / | 0.653 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.652 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.652 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.651 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.650 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.650 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.650 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.650 |