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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gwr EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1gwr ESTEstrogen receptor / 1.165
5dxg ESTEstrogen receptor / 1.092
4pxm ESTEstrogen receptor / 1.086
5hyr ESTEstrogen receptor / 1.084
2yja ESTEstrogen receptor / 1.070
3uud ESTEstrogen receptor / 1.065
3q95 ESLEstrogen receptor / 1.035
2qgt EEDEstrogen receptor / 1.028
3l03 4OHEstrogen receptor / 1.018
5dx3 ESTEstrogen receptor / 0.996
2p15 EZTEstrogen receptor / 0.983
2j7x ESTEstrogen receptor beta / 0.964
3oll ESTEstrogen receptor beta / 0.946
2b1z 17MEstrogen receptor / 0.931
2ocf ESTEstrogen receptor / 0.899
2g5o DRQEstrogen receptor / 0.894
2yat EEUEstrogen receptor / 0.883
1g50 ESTEstrogen receptor / 0.839
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.744
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.725
1lhu ESTSex hormone-binding globulin / 0.723
3s79 ASDAromatase 1.14.14.14 0.720
4j26 ESTEstrogen receptor beta / 0.718
3gkj HC3Niemann-Pick C1 protein / 0.713
2pnu ENMAndrogen receptor / 0.711
4j24 ESTEstrogen receptor beta / 0.711
1lhw ESMSex hormone-binding globulin / 0.709
1sqn NDRProgesterone receptor / 0.707
3w5p 4OAVitamin D3 receptor / 0.704
4hlw TESAndrogen receptor / 0.700
2aa5 STRMineralocorticoid receptor / 0.696
4at2 ASDPossible succinate dehydrogenase / 0.695
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.695
1lri CLRBeta-elicitin cryptogein / 0.688
1x78 244Estrogen receptor beta / 0.686
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.684
1x7e 244Estrogen receptor / 0.683
2qa8 GENEstrogen receptor / 0.681
2pog WSTEstrogen receptor / 0.679
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.679
4q0a 4OAVitamin D3 receptor A / 0.678
1x7r GENEstrogen receptor / 0.677
2w8y 486Progesterone receptor / 0.677
4y8w STRSteroid 21-hydroxylase / 0.675
3w5q 3KLVitamin D3 receptor / 0.673
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.672
2y02 Y01Beta-1 adrenergic receptor / 0.671
4apu A2KProgesterone receptor / 0.671
2qe4 JJ3Estrogen receptor / 0.670
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.667
2aib ERGBeta-elicitin cinnamomin / 0.666
4e5l DBHPolymerase acidic protein / 0.666
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.664
4ivy 1GTEstrogen receptor / 0.664
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
2nv7 555Estrogen receptor beta / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5f 0N7Polymerase acidic protein / 0.659
4a2j AS0Progesterone receptor / 0.658
4zn7 DESEstrogen receptor / 0.658
2mm3 GCHGastrotropin / 0.657
4dma 0L8Estrogen receptor / 0.657
1ot7 CHCBile acid receptor / 0.654
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.651
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.651
1sr7 MOFProgesterone receptor / 0.650