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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1e1v CMG Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.786
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1e1x NW1Cyclin-dependent kinase 2 2.7.11.22 0.721
1h0v UN4Cyclin-dependent kinase 2 2.7.11.22 0.706
2pvy ACPFibroblast growth factor receptor 2 / 0.688
3b2t M33Fibroblast growth factor receptor 2 / 0.680
1h1p CMGCyclin-dependent kinase 2 2.7.11.22 0.673
4b8l A0PAurora kinase B-A 2.7.11.1 0.673
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.672
4xhg ADPUncharacterized protein / 0.668
3r71 X86Cyclin-dependent kinase 2 2.7.11.22 0.667
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.663
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.662
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.658
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.658
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.658
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.656
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
4j97 ACPFibroblast growth factor receptor 2 / 0.654
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.653
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.653
4gu9 4GUFocal adhesion kinase 1 2.7.10.2 0.653
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.652
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.651
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.651
1ad5 ANPTyrosine-protein kinase HCK 2.7.10.2 0.650
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.650