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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dxo FAD NAD(P)H dehydrogenase [quinone] 1 1.6.5.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.283
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.224
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.222
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.142
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.140
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.123
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.118
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.117
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.056
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.984
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.983
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.978
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.976
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.973
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.969
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.953
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.949
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.896
4gi5 FADPutative NAD(P)H dehydrogenase (Quinone) / 0.865
3rpe FADPutative modulator of drug activity / 0.795
3klb FMNUncharacterized protein / 0.791
2b3d FADModulator of drug activity B / 0.790
3lcm FADPutative oxidoreductase / 0.785
4j8p FMNFlavodoxin / 0.783
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.763
1t5b FMNFMN-dependent NADH-azoreductase / 0.755
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.744
2pg0 FADAcyl-CoA dehydrogenase / 0.738
4n9q FMNFMN-dependent NADH-azoreductase 1 / 0.728
2z9d FMNFMN-dependent NADH-azoreductase / 0.723
1ych FMNNitric oxide reductase 1 0.720
2ohj FMNType A flavoprotein FprA 1 0.718
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.717
3zho FMNNAD(P)H dehydrogenase (quinone) / 0.714
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.713
2hpv FMNFMN-dependent NADH-azoreductase 1.7 0.711
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.709
4r81 FMNPredicted NADH dehydrogenase / 0.708
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.702
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.702
3l67 FMNXenobiotic reductase / 0.698
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.698
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.692
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.689
4tmb FMNOld yellow enzyme / 0.688
4cw5 FMNDfnA / 0.687
3w77 FMNFMN-dependent NADH-azoreductase / 0.686
4yco FMNtRNA-dihydrouridine(16) synthase / 0.686
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.685
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.685
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.684
2ohi FMNType A flavoprotein FprA 1 0.684
4dy4 FMNNAD(P)H dehydrogenase (quinone) / 0.684
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.684
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.682
1t0i FMNNAD(P)H-dependent FMN reductase LOT6 / 0.679
3u33 FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.679
4tmc FMNOld yellow enzyme / 0.679
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.677
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.677
1t9g FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.673
4hs4 FMNChromate reductase / 0.673
4z38 FMNMlnA / 0.673
3mpj FADGlutaryl-CoA dehydrogenase 1.3.99.32 0.672
2r97 FMNNAD(P)H dehydrogenase (quinone) / 0.668
3w8w FADPutative FAD-dependent oxygenase EncM / 0.668
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.667
2gjn FMNNitronate monooxygenase 1.13.12.16 0.666
1gwj FMNMorphinone reductase / 0.665
3p67 FMNPentaerythritol tetranitrate reductase / 0.665
3p8j FMNPentaerythritol tetranitrate reductase / 0.665
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.664
4p13 FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.663
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.662
1vyr FMNPentaerythritol tetranitrate reductase / 0.662
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.661
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.661
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.661
4utl FNRXenobiotic reductase / 0.661
4utm FNRXenobiotic reductase / 0.660
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.659
3atz FMNProstaglandin F2a synthase / 0.659
4qai FMNNADPH dehydrogenase / 0.659
4utk FNRXenobiotic reductase / 0.659
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.658
1h63 FMNPentaerythritol tetranitrate reductase / 0.657
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.657
3p84 FMNPentaerythritol tetranitrate reductase / 0.657
3tjl FMNNADPH dehydrogenase / 0.657
5f12 FMNNAD(P)H dehydrogenase (quinone) / 0.657
5j60 FADThioredoxin reductase / 0.657
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.656
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.655
2abb FMNPentaerythritol tetranitrate reductase / 0.654
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.653
3n3a FMNProtein NrdI / 0.651
4e2d FMNDehydrogenase / 0.651
1z48 FMNNADPH dehydrogenase / 0.650
3owa FADAcyl-CoA dehydrogenase / 0.650
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.650