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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1day GNP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1day GNPCasein kinase II subunit alpha 2.7.11.1 1.151
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.986
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.888
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.878
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.834
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.799
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.787
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.772
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.770
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.770
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
5iqb GNPBifunctional AAC/APH 2.3.1 0.750
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.736
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.732
2pyw ADPMethylthioribose kinase 2.7.1.100 0.730
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.729
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.728
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.726
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.714
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.711
1m0w ANPGlutathione synthetase 6.3.2.3 0.710
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.710
5byl GCPBifunctional AAC/APH 2.3.1 0.709
2hgs ADPGlutathione synthetase 6.3.2.3 0.707
2pui ADPMethylthioribose kinase 2.7.1.100 0.707
4ysj ADPCalmodulin-like domain protein kinase / 0.706
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.704
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.702
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.702
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.699
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.697
5iqh GNPBifunctional AAC/APH 2.3.1 0.696
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.695
5ce3 ADPProtein kinase YopO / 0.695
5iqg GDPBifunctional AAC/APH 2.3.1 0.694
5iqd GNPBifunctional AAC/APH 2.3.1 0.693
4ffr ATPUncharacterized protein / 0.691
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.689
5dn3 ATPAurora kinase A 2.7.11.1 0.689
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.687
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.684
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.682
5dt3 ATPAurora kinase A 2.7.11.1 0.682
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.680
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.680
5iqe GNPBifunctional AAC/APH 2.3.1 0.680
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.679
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.679
4utd ACPAurora kinase A 2.7.11.1 0.679
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.678
5iqa GNPBifunctional AAC/APH 2.3.1 0.677
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.676
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.676
5iqi GNPBifunctional AAC/APH 2.3.1 0.676
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.673
2py3 ACPFibroblast growth factor receptor 2 / 0.673
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.672
4ceg ADPAurora kinase A 2.7.11.1 0.672
4qny ANPMitogen activated protein kinase, putative / 0.672
4ffl ADPUncharacterized protein / 0.671
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.670
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.670
3ufx GDPSuccinate--CoA ligase [GDP-forming] subunit beta / 0.669
3bu5 ATPInsulin receptor 2.7.10.1 0.668
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.668
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.668
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.668
3cly ACPFibroblast growth factor receptor 2 / 0.667
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.666
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.665
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.665
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3wnz ADPAlanine--anticapsin ligase / 0.663
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
2pun ACPMethylthioribose kinase 2.7.1.100 0.661
3tdw GDPGentamicin resistance protein / 0.661
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.660
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.659
4dee ADPAurora kinase A 2.7.11.1 0.659
4bn1 ADPAurora kinase A 2.7.11.1 0.658
4dt9 GMPAPH(2'')-Id / 0.658
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.658
1e1q ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.657
2pz5 ACPFibroblast growth factor receptor 2 / 0.657
3dyh 721Farnesyl pyrophosphate synthase / 0.656
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
2b51 UTPRNA editing complex protein MP57 / 0.655
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.655
1cm8 ANPMitogen-activated protein kinase 12 / 0.654
1e79 ADPATP synthase subunit alpha, mitochondrial / 0.654
1e79 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.654
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.653
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.653
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.653
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1ayl ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.651
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
3orm AGSSerine/threonine protein kinase / 0.651
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.651
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.650
3ori AGSSerine/threonine protein kinase / 0.650
4o4d ATPKinase / 0.650