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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ah4 NAP Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ah4 NAPAldose reductase 1.1.1.21 1.680
2acq NAPAldose reductase 1.1.1.21 1.436
3v36 NAPAldose reductase 1.1.1.21 1.396
2j8t NAPAldose reductase 1.1.1.21 1.388
2iq0 NAPAldose reductase 1.1.1.21 1.374
3q67 NAPAldose reductase 1.1.1.21 1.371
1x98 NAPAldose reductase 1.1.1.21 1.348
1ads NAPAldose reductase 1.1.1.21 1.339
2pf8 NDPAldose reductase 1.1.1.21 1.304
1z8a NAPAldose reductase 1.1.1.21 1.291
1x96 NAPAldose reductase 1.1.1.21 1.289
2pev NDPAldose reductase 1.1.1.21 1.288
2acs NAPAldose reductase 1.1.1.21 1.277
3q65 NAPAldose reductase 1.1.1.21 1.256
2acu NAPAldose reductase 1.1.1.21 1.253
2bgs NDPAldose reductase 1.1.1.21 1.223
3qkz NAPAldose reductase-related protein 1 1.1.1.21 1.210
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 1.167
1ef3 NAPAldose reductase 1.1.1.21 1.158
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.155
4g5d NDPProstaglandin F synthase 1.1.1.188 1.107
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 1.095
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.095
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 1.094
5c7h NDPPutative oxidoreductase / 1.094
4pmj NAPPutative oxidoreductase / 1.089
2vdg NDPAldose reductase 1.1.1.21 1.069
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 1.068
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.065
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.060
1c9w NAPAldose reductase-related protein 2 / 1.027
2pfh NDPAldose reductase 1.1.1.21 1.027
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.012
1az2 NAPAldose reductase 1.1.1.21 0.986
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.977
3h7r NAPAldo-keto reductase family 4 member C8 / 0.971
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.945
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.920
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.919
4jtq NAPAldo-keto reductase family 1 member C2 / 0.914
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.908
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.906
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.905
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.894
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.890
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.874
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.871
3wcz NAPAldo-keto reductase AKR2E4 / 0.870
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.864
2hdj NDPAldo-keto reductase family 1 member C2 / 0.850
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.850
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.845
4l1x NAPAldo-keto reductase family 1 member C2 / 0.842
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.838
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.837
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.818
1s1p NAPAldo-keto reductase family 1 member C3 / 0.816
1s1r NAPAldo-keto reductase family 1 member C3 / 0.808
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.804
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.801
1gve NAPAflatoxin B1 aldehyde reductase member 3 1 0.745
1lqa NDPProtein tas / 0.736
3wg6 NDPNADPH-dependent conjugated polyketone reductase C1 / 0.733
1qrq NDPVoltage-gated potassium channel subunit beta-2 / 0.727
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.703
1zgd NAPChalcone reductase / 0.699
1lwi NAP3-alpha-hydroxysteroid dehydrogenase 1.1.1.50 0.692
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.690
3ln3 NADAldo-keto reductase family 1 member C13 / 0.677
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.676
3lnm NAPVoltage-gated potassium channel subunit beta-2 / 0.676
2jj2 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.670
4jtc NAPVoltage-gated potassium channel subunit beta-2 / 0.667
4aub NAPL-glyceraldehyde 3-phosphate reductase 1.1.1 0.665
4g0n GNPGTPase HRas / 0.652
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.650