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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5i2hAGIO-methyltransferase family 2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5i2hAGIO-methyltransferase family 2/1.000
4g2gTDHMycocyclosin synthase1.14.21.90.472
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
2jn3JN3Fatty acid-binding protein, liver/0.464
4g47TZFMycocyclosin synthase1.14.21.90.464
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4l8u9AZSerum albumin/0.459
4iq71G9Mycocyclosin synthase1.14.21.90.456
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3icsADPCoenzyme A disulfide reductase/0.453
4jk3NADUncharacterized protein/0.453
4g48PZBMycocyclosin synthase1.14.21.90.449
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3ictADPCoenzyme A disulfide reductase/0.448
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4ips1G4Mycocyclosin synthase1.14.21.90.446
4ktl1CQCytochrome P450/0.446
1eioGCHGastrotropin/0.445
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.445
1osvCHCBile acid receptor/0.444
4ktkKTKCytochrome P450/0.442
4phlPILPhosphodiesterase/0.442
2cig1DGDihydrofolate reductase1.5.1.30.440