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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5fx2FMNFlavodoxin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5fx2FMNFlavodoxin/1.000
1fx1FMNFlavodoxin/0.594
1akwFMNFlavodoxin/0.562
1akrFMNFlavodoxin/0.559
4fx2FMNFlavodoxin/0.555
1c7fFMNFlavodoxin/0.545
1azlFMNFlavodoxin/0.538
1j9gFMNFlavodoxin/0.537
2fx2FMNFlavodoxin/0.534
1wsbFMNFlavodoxin/0.530
1bu5RBFFlavodoxin/0.529
1j8qFMNFlavodoxin/0.527
5tgzFMNCannabinoid receptor 1/0.523
3f6rFMNFlavodoxin/0.522
1akuFMNFlavodoxin/0.508
4y7cFMNNADPH--cytochrome P450 reductase/0.498
5xraFMNCannabinoid receptor 1/0.496
3ojxFMNNADPH--cytochrome P450 reductase/0.495
1xyvFMNFlavodoxin/0.482
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.475
1j9zFMNNADPH--cytochrome P450 reductase/0.466
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.464
2r5nTPPTransketolase 1/0.464
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.460
1gpuTHDTransketolase 12.2.1.10.460
2r8pT6FTransketolase 1/0.458
2xlrFADPutative flavin-containing monooxygenase/0.458
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.457
5a4vQUEGlutathione S-transferase F22.5.1.180.457
2xysSY9Soluble acetylcholine receptor/0.456
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.456
4twnB96Ephrin type-A receptor 32.7.10.10.454
3wznBTNStreptavidin/0.453
2fcrFMNFlavodoxin/0.451
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3fktSIIBeta-secretase 13.4.23.460.449
3hr4FMNNitric oxide synthase, inducible1.14.13.390.449
1jqdSAHHistamine N-methyltransferase2.1.1.80.448
1e66HUXAcetylcholinesterase3.1.1.70.446
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2r8oT5XTransketolase 1/0.446
2vceU2FUDP-glycosyltransferase 72B1/0.446
3ig6438Urokinase-type plasminogen activator3.4.21.730.446
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.445
4b78KGGBeta-secretase 13.4.23.460.445
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.444
3kaqFMNFlavodoxin/0.444
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.443
4y0kNAPAntE/0.443
1fmjRTLRetinol dehydratase/0.442
2evcFC3Methionine aminopeptidase/0.442
2j3qTFLAcetylcholinesterase3.1.1.70.442
2qimZEAClass 10 plant pathogenesis-related protein/0.442
4e32DWNMethyltransferase/0.442
1njjORXOrnithine decarboxylase/0.441
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3jq6DX1Pteridine reductase, putative/0.440
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440