sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5dxa | SFG | Histone-arginine methyltransferase CARM1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5dxa | SFG | Histone-arginine methyltransferase CARM1 | / | 1.000 | |
| 5dx8 | SFG | Histone-arginine methyltransferase CARM1 | / | 0.674 | |
| 5dxj | SFG | Histone-arginine methyltransferase CARM1 | / | 0.607 | |
| 5dx1 | SFG | Histone-arginine methyltransferase CARM1 | / | 0.591 | |
| 2y1w | SFG | Histone-arginine methyltransferase CARM1 | / | 0.572 | |
| 2y1x | SAH | Histone-arginine methyltransferase CARM1 | / | 0.563 | |
| 1f3l | SAH | Protein arginine N-methyltransferase 3 | / | 0.559 | |
| 5dwq | SFG | Histone-arginine methyltransferase CARM1 | / | 0.557 | |
| 2a14 | SAH | Indolethylamine N-methyltransferase | 2.1.1.49 | 0.515 | |
| 4c03 | SFG | Protein arginine N-methyltransferase 6 | / | 0.510 | |
| 2bzg | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.484 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.476 | |
| 3up3 | XCA | aceDAF-12 | / | 0.476 | |
| 2i62 | SAH | Nicotinamide N-methyltransferase | 2.1.1.1 | 0.470 | |
| 4e2x | SAH | Methyltransferase | / | 0.466 | |
| 4kwc | SAH | Methyltransferase domain family | / | 0.463 | |
| 3up0 | D7S | aceDAF-12 | / | 0.461 | |
| 2kce | D16 | Thymidylate synthase | / | 0.458 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.457 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.457 | |
| 2zwa | SAH | tRNA wybutosine-synthesizing protein 4 | 2.1.1.290 | 0.455 | |
| 3bgv | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.454 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.454 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.453 | |
| 4ax8 | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.453 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.452 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 2zw9 | SAM | tRNA wybutosine-synthesizing protein 4 | 2.1.1.290 | 0.449 | |
| 3p9k | SAH | Caffeic acid O-methyltransferase | / | 0.449 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.449 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.447 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 2qcu | FAD | Aerobic glycerol-3-phosphate dehydrogenase | 1.1.5.3 | 0.444 | |
| 2v74 | SAH | Histone-arginine methyltransferase CARM1 | / | 0.444 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4krh | SAM | Phosphoethanolamine N-methyltransferase 2 | / | 0.444 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.443 | |
| 4l0t | 1V0 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.442 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.442 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 5je2 | SAH | Methyl transferase | / | 0.441 | |
| 1lke | DOG | Bilin-binding protein | / | 0.440 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 |