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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5bntNAPAspartate-semialdehyde dehydrogenase1.2.1.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5bntNAPAspartate-semialdehyde dehydrogenase1.2.1.111.000
2cy0NAPShikimate dehydrogenase (NADP(+))/0.478
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.475
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.473
1mb4NDPAspartate-semialdehyde dehydrogenase 1/0.459
3pzrNAPAspartate-semialdehyde dehydrogenase 1/0.451
3fwgCAMCamphor 5-monooxygenase1.14.15.10.449
3wrhCAMCamphor 5-monooxygenase1.14.15.10.449
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.447
1nooCAHCamphor 5-monooxygenase1.14.15.10.446
1gl3NDPAspartate-semialdehyde dehydrogenase/0.445
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2ev9NAPShikimate dehydrogenase (NADP(+))/0.444
3fwjCAMCamphor 5-monooxygenase1.14.15.10.444
4q71FADBifunctional protein PutA/0.444
2d8aNADL-threonine 3-dehydrogenase/0.442
1b8uNADMalate dehydrogenase/0.441
1h50FMNPentaerythritol tetranitrate reductase/0.441
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.441
4ejmNAPPutative zinc-binding dehydrogenase/0.440
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440