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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yao2AMNADPH--cytochrome P450 reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4yao2AMNADPH--cytochrome P450 reductase/1.000
4y9uNAPNADPH--cytochrome P450 reductase/0.607
4yaw2AMNADPH--cytochrome P450 reductase/0.597
4yau2AMNADPH--cytochrome P450 reductase/0.588
4y9rNAPNADPH--cytochrome P450 reductase/0.584
4yal2AMNADPH--cytochrome P450 reductase/0.580
4y7cNAPNADPH--cytochrome P450 reductase/0.568
4yaf2AMNADPH--cytochrome P450 reductase/0.551
1amoNAPNADPH--cytochrome P450 reductase/0.548
3qfsNAPNADPH--cytochrome P450 reductase/0.530
3qfcNAPNADPH--cytochrome P450 reductase/0.507
3qfrNAPNADPH--cytochrome P450 reductase/0.504
2bpoNAPNADPH--cytochrome P450 reductase/0.492
3qe2NAPNADPH--cytochrome P450 reductase/0.489
2bf4NAPNADPH--cytochrome P450 reductase/0.485
1ja1NAPNADPH--cytochrome P450 reductase/0.477
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.468
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.468
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
1o9bNAIQuinate/shikimate dehydrogenase/0.465
2j2pSC2Ficolin-2/0.461
1tllNAPNitric oxide synthase, brain1.14.13.390.460
1je1GMPPurine nucleoside phosphorylase/0.458
1vbmYSATyrosine--tRNA ligase6.1.1.10.457
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.457
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.453
3to3ATPPetrobactin biosynthesis protein AsbB/0.452
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.451
2cy0NAPShikimate dehydrogenase (NADP(+))/0.450
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.450
2ed3SAHDiphthine synthase/0.449
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.448
2oxnOANBeta-hexosaminidase/0.448
3lm8VIBThiamine pyrophosphokinase2.7.6.20.448
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3rbaCODPhosphopantetheine adenylyltransferase/0.446
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.445
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
4j7hTRHPCZA361.3/0.443
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.443
2rqfJH3Hemolymph juvenile hormone binding protein/0.442
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.441
2bn4NAPNADPH--cytochrome P450 reductase/0.441
2wjoQUDBeta-secretase 13.4.23.460.441
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.441
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.440