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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.301.000
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.568
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.541
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.525
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.507
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.506
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.504
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.498
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.496
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.495
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.491
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.483
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.479
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.476
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.463
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.449
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.448