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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pmjNAPPutative oxidoreductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4pmjNAPPutative oxidoreductase/1.000
5c7hNDPPutative oxidoreductase/0.662
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.542
4jtqNAPAldo-keto reductase family 1 member C2/0.528
2hdjNDPAldo-keto reductase family 1 member C2/0.527
3h7rNAPAldo-keto reductase family 4 member C8/0.526
4g5dNDPProstaglandin F synthase1.1.1.1880.526
1c9wNAPAldose reductase-related protein 2/0.519
2pfhNDPAldose reductase1.1.1.210.518
2j8tNAPAldose reductase1.1.1.210.514
1az2NAPAldose reductase1.1.1.210.512
1x96NAPAldose reductase1.1.1.210.512
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.511
2pf8NDPAldose reductase1.1.1.210.510
3v36NAPAldose reductase1.1.1.210.509
4xo7NAPAldo-keto reductase family 1 member C2/0.506
2acqNAPAldose reductase1.1.1.210.504
2pevNDPAldose reductase1.1.1.210.503
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.501
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.500
3q65NAPAldose reductase1.1.1.210.497
2iq0NAPAldose reductase1.1.1.210.496
1adsNAPAldose reductase1.1.1.210.495
1ah4NAPAldose reductase1.1.1.210.494
1x98NAPAldose reductase1.1.1.210.494
4dz5NAPAldo-keto reductase family 1 member C3/0.494
1z8aNAPAldose reductase1.1.1.210.492
2hejNDPAldo-keto reductase family 1 member C211.1.10.492
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.491
4jq3NAPAldo-keto reductase family 1 member C2/0.490
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.488
1vp5NAPOxidoreductase, aldo/keto reductase family/0.486
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.484
3q67NAPAldose reductase1.1.1.210.484
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.481
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.479
2acsNAPAldose reductase1.1.1.210.473
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.472
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.471
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.470
2acuNAPAldose reductase1.1.1.210.469
3qkzNAPAldose reductase-related protein 11.1.1.210.460
1zgdNAPChalcone reductase/0.458
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.458
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.457
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.455
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
3o3rNAPAldose reductase-related protein 11.1.1.210.453
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.451
2p5nNDPAldo-keto reductase family 1 member C211.1.10.449
3wczNAPAldo-keto reductase AKR2E4/0.448
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.446
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.443
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.442
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.441
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.440
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.440