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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nka2K7Fibroblast growth factor receptor 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4nka2K7Fibroblast growth factor receptor 1/1.000
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.508
2c6eHPMAurora kinase A2.7.11.10.506
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.506
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.499
4nks2M2Fibroblast growth factor receptor 1/0.494
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.490
4nk92K5Fibroblast growth factor receptor 1/0.488
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.484
3l8p0CEAngiopoietin-1 receptor2.7.10.10.482
2fgiPD1Fibroblast growth factor receptor 1/0.479
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.477
4j97ACPFibroblast growth factor receptor 2/0.477
4f640S8Fibroblast growth factor receptor 1/0.475
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.471
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.470
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.469
3s4qNK0Mitogen-activated protein kinase 14/0.466
3hp552PMitogen-activated protein kinase 14/0.465
3ha85JZMitogen-activated protein kinase 14/0.463
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.459
3uvqFS8Mitogen-activated protein kinase 14/0.459
3fskRO6Mitogen-activated protein kinase 14/0.457
3mpaSB2Mitogen-activated protein kinase 14/0.451
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.451
1bygSTUTyrosine-protein kinase CSK/0.449
4anqVGHALK tyrosine kinase receptor2.7.10.10.449
1zyjBI5Mitogen-activated protein kinase 14/0.447
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.447
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.446
4gmy0X5Tyrosine-protein kinase JAK2/0.446
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.445
4hvh19RTyrosine-protein kinase JAK32.7.10.20.444
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2pvyACPFibroblast growth factor receptor 2/0.443
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
3zsh469Mitogen-activated protein kinase 14/0.443
4eym0RXMitogen-activated protein kinase 132.7.11.240.443
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2yfxVGHALK tyrosine kinase receptor2.7.10.10.442
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.442
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.441
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.441
2v7a627Tyrosine-protein kinase ABL12.7.10.20.441