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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.11.000
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.675
3rgzBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.501
3zkyWT4Isopenicillin N synthase1.21.3.10.483
2y6fM9FIsopenicillin N synthase1.21.3.10.482
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.477
1x1aSAMC-20 methyltransferase/0.471
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.471
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.464
4pnmNU1Tankyrase-22.4.2.300.463
2vbpVB1Isopenicillin N synthase1.21.3.10.462
1pz1NAPGeneral stress protein 69/0.459
2vcmM11Isopenicillin N synthase1.21.3.10.459
1qiqACCIsopenicillin N synthase1.21.3.10.457
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.457
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.456
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.455
4at0FADPossible succinate dehydrogenase/0.454
2ociTYCValacyclovir hydrolase3.10.453
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.453
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.453
1odcA8BAcetylcholinesterase3.1.1.70.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.452
4iaq2GM5-hydroxytryptamine receptor 1B/0.452
1ygjRMCPyridoxal kinase2.7.1.350.451
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.451
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1p8dCO1Oxysterols receptor LXR-beta/0.449
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.449
3ojxFMNNADPH--cytochrome P450 reductase/0.448
1oc1ASVIsopenicillin N synthase1.21.3.10.447
2f3815MAldo-keto reductase family 1 member C3/0.447
4rvdSAMD-mycarose 3-C-methyltransferase/0.447
2lfoGCHFatty acid-binding protein, liver/0.446
2wo7ASVIsopenicillin N synthase1.21.3.10.446
2zsaADPPantothenate kinase2.7.1.330.446
1yhjR6CPyridoxal kinase2.7.1.350.445
4jeyPLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.445
4xo7NAPAldo-keto reductase family 1 member C2/0.445
1blzACVIsopenicillin N synthase1.21.3.10.444
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.443
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.443
2fs4PZ1Renin3.4.23.150.442
2rd2QSIGlutamine--tRNA ligase6.1.1.180.442
4eph0RKCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.442
4jqh1MFAlr2278 protein/0.442
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.442
1hb1OCVIsopenicillin N synthase1.21.3.10.441
1pqc444Oxysterols receptor LXR-beta/0.441
1vkgCRIHistone deacetylase 83.5.1.980.441
2gesCOKPantothenate kinase2.7.1.330.441
2z3uCRRCytochrome P450/0.441
3gncQQQGlutaryl-CoA dehydrogenase/0.441
1zgbA1EAcetylcholinesterase3.1.1.70.440
1zgcA2EAcetylcholinesterase3.1.1.70.440
3aezGDPPantothenate kinase2.7.1.330.440
4iarERM5-hydroxytryptamine receptor 1B/0.440
4m4821BSodium-dependent dopamine transporter/0.440
4zasTYDCalS13/0.440