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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l2k1V8Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l2k1V8Tankyrase-22.4.2.301.000
4buxF35Tankyrase-22.4.2.300.673
4l341VGTankyrase-22.4.2.300.669
4j22AJ7Tankyrase-22.4.2.300.665
4l0s1UZTankyrase-22.4.2.300.663
4l0i1UWTankyrase-22.4.2.300.660
4l31F08Tankyrase-22.4.2.300.657
4avwG18Tankyrase-22.4.2.300.653
4bueJQFTankyrase-22.4.2.300.653
4hlf15ZTankyrase-22.4.2.300.653
4l2g1V4Tankyrase-22.4.2.300.653
4l33F70Tankyrase-22.4.2.300.653
4bufF36Tankyrase-22.4.2.300.650
4hkkAGITankyrase-22.4.2.300.650
4iueAJ4Tankyrase-22.4.2.300.650
4l0v1V1Tankyrase-22.4.2.300.650
5aku29FTankyrase-22.4.2.300.650
4l0t1V0Tankyrase-22.4.2.300.648
4hl515WTankyrase-22.4.2.300.647
4bud29FTankyrase-22.4.2.300.645
4bu908CTankyrase-22.4.2.300.642
4l321VFTankyrase-22.4.2.300.641
4buuF38Tankyrase-22.4.2.300.634
4l2f1V3Tankyrase-22.4.2.300.632
4hlm16STankyrase-22.4.2.300.617
4bus32FTankyrase-22.4.2.300.616
4kzl20DTankyrase-22.4.2.300.616
4hlh20DTankyrase-22.4.2.300.614
4buiW2ETankyrase-22.4.2.300.612
4j21AJ6Tankyrase-22.4.2.300.592
4hkiFLNTankyrase-22.4.2.300.589
3p0pNNFTankyrase-22.4.2.300.587
4hmhF94Tankyrase-22.4.2.300.577
4bj9UHBTankyrase-22.4.2.300.575
3u9y09LTankyrase-22.4.2.300.572
4pnrG18Tankyrase-22.4.2.300.569
4bs4A64Tankyrase-22.4.2.300.568
4tkg09LTankyrase-22.4.2.300.556
4buwF33Tankyrase-22.4.2.300.554
4pnmNU1Tankyrase-22.4.2.300.515
4bjbP34Tankyrase-22.4.2.300.504
4avuLDRTankyrase-22.4.2.300.499
4buv16ITankyrase-22.4.2.300.497
4tjy3GNTankyrase-22.4.2.300.496
4msk2C8Tankyrase-12.4.2.300.483
4j3mAJ8Tankyrase-22.4.2.300.482
2dw4FADLysine-specific histone demethylase 1A10.477
4l091URTankyrase-22.4.2.300.477
4j3lAJ5Tankyrase-22.4.2.300.471
2bf7HBIPteridine reductase 11.5.1.330.454
3mauPLRPutative sphingosine-1-phosphate lyase/0.452
4k4eK4ETankyrase-12.4.2.300.449
3h4vDVPPteridine reductase 11.5.1.330.444
2bfaCB3Pteridine reductase 11.5.1.330.443
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.442
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.440