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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.211.000
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.594
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.588
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.568
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.562
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.560
2owb626Serine/threonine-protein kinase PLK12.7.11.210.543
2yac937Serine/threonine-protein kinase PLK12.7.11.210.539
2z2w770Wee1-like protein kinase2.7.10.20.522
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.521
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.493
2in6839Wee1-like protein kinase2.7.10.20.489
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.485
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.481
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.473
3biz61EWee1-like protein kinase2.7.10.20.473
3cr0809Wee1-like protein kinase2.7.10.20.471
3h4vDVPPteridine reductase 11.5.1.330.471
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.470
3bi6396Wee1-like protein kinase2.7.10.20.466
2bf7HBIPteridine reductase 11.5.1.330.463
3cqeP91Wee1-like protein kinase2.7.10.20.462
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.461
5dp2NAPCurF/0.461
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.458
2wd8VGFPteridine reductase/0.457
3h4vNAPPteridine reductase 11.5.1.330.457
2bfaCB3Pteridine reductase 11.5.1.330.455
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.455
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.454
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.453
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.453
2io6330Wee1-like protein kinase2.7.10.20.451
3hl0NADMaleylacetate reductase/0.450
2gjlFMNNitronate monooxygenase1.13.12.160.448
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.448
3cth319Hepatocyte growth factor receptor2.7.10.10.448
1x8b824Wee1-like protein kinase2.7.10.20.447
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.447
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.445
3d5wADPSerine/threonine-protein kinase PLK/0.445
4k9yK9YFocal adhesion kinase 12.7.10.20.444
3ctj320Hepatocyte growth factor receptor2.7.10.10.442
4bftZVTPantothenate kinase2.7.1.330.441
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440