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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hlf15ZTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hlf15ZTankyrase-22.4.2.301.000
4l10A63Tankyrase-22.4.2.300.731
4kzl20DTankyrase-22.4.2.300.679
4bueJQFTankyrase-22.4.2.300.652
4l2f1V3Tankyrase-22.4.2.300.652
4bufF36Tankyrase-22.4.2.300.648
4l0v1V1Tankyrase-22.4.2.300.646
4hkkAGITankyrase-22.4.2.300.644
4l321VFTankyrase-22.4.2.300.641
4hlh20DTankyrase-22.4.2.300.630
4avwG18Tankyrase-22.4.2.300.629
4iueAJ4Tankyrase-22.4.2.300.627
4buxF35Tankyrase-22.4.2.300.623
4bud29FTankyrase-22.4.2.300.619
4hl515WTankyrase-22.4.2.300.618
4l31F08Tankyrase-22.4.2.300.618
4l0i1UWTankyrase-22.4.2.300.614
4buuF38Tankyrase-22.4.2.300.611
4j21AJ6Tankyrase-22.4.2.300.611
4l33F70Tankyrase-22.4.2.300.611
4hknLU2Tankyrase-22.4.2.300.610
4j22AJ7Tankyrase-22.4.2.300.607
4hlm16STankyrase-22.4.2.300.606
4buiW2ETankyrase-22.4.2.300.603
4l0t1V0Tankyrase-22.4.2.300.602
4l0s1UZTankyrase-22.4.2.300.601
4l2k1V8Tankyrase-22.4.2.300.601
4kzuA73Tankyrase-22.4.2.300.598
5aku29FTankyrase-22.4.2.300.597
4bu908CTankyrase-22.4.2.300.596
3p0pNNFTankyrase-22.4.2.300.595
4bus32FTankyrase-22.4.2.300.591
4but31FTankyrase-22.4.2.300.589
4l2g1V4Tankyrase-22.4.2.300.587
3kr8XAVTankyrase-22.4.2.300.585
4l341VGTankyrase-22.4.2.300.580
4bj9UHBTankyrase-22.4.2.300.577
4hlk431Tankyrase-22.4.2.300.569
4pnrG18Tankyrase-22.4.2.300.567
4tkg09LTankyrase-22.4.2.300.544
4hkiFLNTankyrase-22.4.2.300.543
4hmhF94Tankyrase-22.4.2.300.542
4msk2C8Tankyrase-12.4.2.300.530
4pnmNU1Tankyrase-22.4.2.300.530
4buwF33Tankyrase-22.4.2.300.519
4bjbP34Tankyrase-22.4.2.300.509
4bs4A64Tankyrase-22.4.2.300.503
4l091URTankyrase-22.4.2.300.484
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.479
4tjy3GNTankyrase-22.4.2.300.479
4k4eK4ETankyrase-12.4.2.300.467
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.464
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.450
1xf0ASDAldo-keto reductase family 1 member C3/0.448
2xlrFADPutative flavin-containing monooxygenase/0.446
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.446
3w0c6DSVitamin D3 receptor/0.444
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.443
2ejzSAHDiphthine synthase/0.442
3rsv3RSBeta-secretase 13.4.23.460.442
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.441
4i9i1DYTankyrase-12.4.2.300.441
1knrFADL-aspartate oxidase1.4.3.160.440