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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.757
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.673
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.656
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.631
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.593
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.587
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.571
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.558
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.548
3iczPB6Farnesyl pyrophosphate synthase/0.544
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.525
3egt722Farnesyl pyrophosphate synthase/0.519
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.498
3dyh721Farnesyl pyrophosphate synthase/0.491
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.481
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.475
4bfxZVXPantothenate kinase2.7.1.330.462
4blrUTPNTPase P4/0.457
1rqjRISFarnesyl diphosphate synthase2.5.1.100.453
2ekaSAHDiphthine synthase/0.453
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.453
1gebCAMCamphor 5-monooxygenase1.14.15.10.452
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.451
3rywK9HFarnesyl pyrophosphate synthase, putative/0.449
3oabDSTGeranyl diphosphate synthase large subunit/0.444
3fwgCAMCamphor 5-monooxygenase1.14.15.10.443
3icpNADNAD-dependent epimerase/dehydratase/0.443
3ql6NIMLactoperoxidase1.11.1.70.443
5irnADPNucleotide binding oligomerization domain containing 2/0.442
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.441
1ppjANYCytochrome b/0.440
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.440