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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g5dNDPProstaglandin F synthase1.1.1.188

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4g5dNDPProstaglandin F synthase1.1.1.1881.000
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.605
2acqNAPAldose reductase1.1.1.210.572
2iq0NAPAldose reductase1.1.1.210.571
2j8tNAPAldose reductase1.1.1.210.566
1az2NAPAldose reductase1.1.1.210.565
1x96NAPAldose reductase1.1.1.210.550
1x98NAPAldose reductase1.1.1.210.548
3v36NAPAldose reductase1.1.1.210.548
2pfhNDPAldose reductase1.1.1.210.546
2acsNAPAldose reductase1.1.1.210.545
1ah4NAPAldose reductase1.1.1.210.527
1adsNAPAldose reductase1.1.1.210.524
3h7rNAPAldo-keto reductase family 4 member C8/0.522
1c9wNAPAldose reductase-related protein 2/0.520
3qkzNAPAldose reductase-related protein 11.1.1.210.519
1z8aNAPAldose reductase1.1.1.210.515
3q65NAPAldose reductase1.1.1.210.510
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.509
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.504
2pevNDPAldose reductase1.1.1.210.504
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.500
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.497
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.494
2pf8NDPAldose reductase1.1.1.210.493
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.492
4jtqNAPAldo-keto reductase family 1 member C2/0.490
2acuNAPAldose reductase1.1.1.210.489
4pmjNAPPutative oxidoreductase/0.489
2bgsNDPAldose reductase1.1.1.210.488
1vp5NAPOxidoreductase, aldo/keto reductase family/0.487
3q67NAPAldose reductase1.1.1.210.487
3o3rNAPAldose reductase-related protein 11.1.1.210.486
4xo7NAPAldo-keto reductase family 1 member C2/0.485
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.484
2hdjNDPAldo-keto reductase family 1 member C2/0.478
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.476
4jq3NAPAldo-keto reductase family 1 member C2/0.475
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.473
1zgdNAPChalcone reductase/0.472
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.468
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.466
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.463
2hejNDPAldo-keto reductase family 1 member C211.1.10.463
3wczNAPAldo-keto reductase AKR2E4/0.460
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.459
1s1rNAPAldo-keto reductase family 1 member C3/0.457
4dz5NAPAldo-keto reductase family 1 member C3/0.457
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.455
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
4l1xNAPAldo-keto reductase family 1 member C2/0.454
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
1og6NAPOxidoreductase YdhF10.449
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.447
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.442
1pz1NAPGeneral stress protein 69/0.441
4jtaNAPVoltage-gated potassium channel subunit beta-2/0.441
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.440