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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv6E57Mitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fv6E57Mitogen-activated protein kinase 12.7.11.241.000
3i60E86Mitogen-activated protein kinase 12.7.11.240.601
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.586
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.534
4fv9E71Mitogen-activated protein kinase 12.7.11.240.515
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.467
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.461
2pvmP29Casein kinase II subunit alpha2.7.11.10.454
4qnyANPMitogen activated protein kinase, putative/0.454
2f2uM77Rho-associated protein kinase 22.7.11.10.453
3nynSGVG protein-coupled receptor kinase 62.7.11.160.452
2yaaATPDeath-associated protein kinase 2/0.451
4f081RSTyrosine-protein kinase JAK2/0.451
4hge15VTyrosine-protein kinase JAK2/0.451
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.446
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
2uzbC75Cyclin-dependent kinase 22.7.11.220.442