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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fk8FADFerredoxin--NADP reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fk8FADFerredoxin--NADP reductase/1.000
1a8pFADFerredoxin--NADP reductase/0.659
2bgiFADNADPH:ferredoxin reductase/0.633
3crzFADFerredoxin--NADP+ reductase/0.612
2vnkFADNADPH:ferredoxin reductase/0.603
2vnjFADNADPH:ferredoxin reductase/0.597
2vnhFADNADPH:ferredoxin reductase/0.593
2qdxFADFerredoxin--NADP+ reductase/0.588
4b4dFADFerredoxin-NADP reductase/0.569
3fpkFADFerredoxin-NADP reductase/0.489
4k1xFADNADPH:ferredoxin reductase/0.487
3tjsD0RCytochrome P450 3A4/0.469
3tk3CPZCytochrome P450 2B41.14.14.10.464
1ja1FADNADPH--cytochrome P450 reductase/0.463
3s1dZIRCytokinin dehydrogenase 11.5.99.120.462
4tuvCPZCytochrome P450 1191.140.458
2ca0PXICytochrome P450 monooxygenase PikC/0.457
4k9u5AWCytochrome P450 3A4/0.457
1xddAAYIntegrin alpha-L/0.456
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.456
4a30MYAGlycylpeptide N-tetradecanoyltransferase/0.454
1j9zFADNADPH--cytochrome P450 reductase/0.453
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.452
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.450
1amoFADNADPH--cytochrome P450 reductase/0.449
1h50FMNPentaerythritol tetranitrate reductase/0.448
4eji0QACytochrome P450 2A131.14.14.10.448
2cy0NAPShikimate dehydrogenase (NADP(+))/0.447
3p62FMNPentaerythritol tetranitrate reductase/0.447
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.447
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.447
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.447
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.446
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.446
1o76CAMCamphor 5-monooxygenase1.14.15.10.445
3p84FMNPentaerythritol tetranitrate reductase/0.445
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
3bc3OPTCathepsin L13.4.22.150.444
3ibdCPZCytochrome P450 2B61.14.130.444
3w5uFADFerredoxin/0.444
4g7gVFVLanosterol 14-alpha-demethylase/0.444
4l4dCAMCamphor 5-monooxygenase1.14.15.10.444
4ejgNCTCytochrome P450 2A131.14.14.10.443
4r21STRCytochrome P450 family 17 polypeptide 2/0.443
1nvtNAPShikimate dehydrogenase (NADP(+))/0.442
2lbaCHOFatty acid binding protein 6/0.442
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.442
4bb3KKAIsopenicillin N synthase1.21.3.10.442
4ejh0QACytochrome P450 2A131.14.14.10.442
3oeeANPATP synthase subunit alpha, mitochondrial/0.441
3oeeANPATP synthase subunit beta, mitochondrial3.6.3.140.441
3uxyNADShort-chain dehydrogenase/reductase SDR/0.441
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
2z3uCRRCytochrome P450/0.440