sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4f7l | 0SO | Cyclin-dependent kinase 8 | 2.7.11.22 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4f7l | 0SO | Cyclin-dependent kinase 8 | 2.7.11.22 | 1.000 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.495 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.491 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.473 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.465 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.459 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.459 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3eej | 53R | Uncharacterized protein | / | 0.458 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 3rps | 4B0 | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.456 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.454 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.452 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.449 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.448 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 1b38 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4fki | 09K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
| 3r34 | COA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.446 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.445 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.445 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.445 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.445 | |
| 2r64 | 740 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3q9w | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.443 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.443 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.443 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.443 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.443 | |
| 4ek6 | 10K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.443 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1oiu | N76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1qmf | KEF | Penicillin-binding protein 2x | / | 0.442 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.442 | |
| 3mfu | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.442 | |
| 3r3c | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.442 | |
| 4h50 | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.442 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.441 | |
| 3r7i | X9I | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.441 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.440 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.440 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.440 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 |